6UMI

Crystal structure of erenumab Fab-b

Summary for 6UMI

Entry DOI	10.2210/pdb6umi/pdb
Related	6UMG 6UMH 6UMJ
Descriptor	erenumab Fab heavy chain, IgG1, erenumab Fab light chain, IgG1 (3 entities in total)
Functional Keywords	fragment antigen binding, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	48310.85
Authors	Mohr, C. (deposition date: 2019-10-09, release date: 2020-02-12, Last modification date: 2020-02-26)
Primary citation	Garces, F.,Mohr, C.,Zhang, L.,Huang, C.S.,Chen, Q.,King, C.,Xu, C.,Wang, Z. Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab). Cell Rep, 30:1714-, 2020 Cited by PubMed: 32049005 DOI: 10.1016/j.celrep.2020.01.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation