6W06
Bruton's tyrosine kinase in complex with compound 6
Summary for 6W06
Entry DOI | 10.2210/pdb6w06/pdb |
Related | 6VXQ |
Descriptor | Tyrosine-protein kinase BTK, DIMETHYL SULFOXIDE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (5 entities in total) |
Functional Keywords | kinase, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34513.72 |
Authors | Metrick, C.M.,Marcotte, D.J. (deposition date: 2020-02-29, release date: 2020-12-16, Last modification date: 2023-10-11) |
Primary citation | Ma, B.,Bohnert, T.,Otipoby, K.L.,Tien, E.,Arefayene, M.,Bai, J.,Bajrami, B.,Bame, E.,Chan, T.R.,Humora, M.,MacPhee, J.M.,Marcotte, D.,Mehta, D.,Metrick, C.M.,Moniz, G.,Polack, E.,Poreci, U.,Prefontaine, A.,Sheikh, S.,Schroeder, P.,Smirnakis, K.,Zhang, L.,Zheng, F.,Hopkins, B.T. Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases. J.Med.Chem., 63:12526-12541, 2020 Cited by PubMed: 32696648DOI: 10.1021/acs.jmedchem.0c00702 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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