6UMG
Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor
Summary for 6UMG
Entry DOI | 10.2210/pdb6umg/pdb |
Related | 6UMH 6UMI 6UMJ |
Descriptor | erenumab Fab heavy chain, IgG1, erenumab Fab light chain, IgG1, Calcitonin gene-related peptide type 1 receptor, ... (5 entities in total) |
Functional Keywords | class b gpcr, complex, fragment antigen binding, membrane protein-immune system complex, membrane protein/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 156842.82 |
Authors | Mohr, C. (deposition date: 2019-10-09, release date: 2020-02-12, Last modification date: 2023-10-11) |
Primary citation | Garces, F.,Mohr, C.,Zhang, L.,Huang, C.S.,Chen, Q.,King, C.,Xu, C.,Wang, Z. Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab). Cell Rep, 30:1714-, 2020 Cited by PubMed: 32049005DOI: 10.1016/j.celrep.2020.01.029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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