6UMG
Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | H, h | erenumab Fab heavy chain, IgG1 | polymer | 237 | 25483.5 | 2 | Homo sapiens (Human) | ||
2 | L, l | erenumab Fab light chain, IgG1 | polymer | 216 | 22827.3 | 2 | Homo sapiens (Human) | ||
3 | C, c | Calcitonin gene-related peptide type 1 receptor | polymer | 139 | 16269.9 | 2 | UniProt (Q16602) Pfam (PF02793) In PDB | Homo sapiens (Human) | CGRP type 1 receptor, Calcitonin receptor-like receptor |
4 | R, r | Receptor activity-modifying protein 1 | polymer | 120 | 13840.7 | 2 | UniProt (O60894) Pfam (PF04901) In PDB | Homo sapiens (Human) | Calcitonin-receptor-like receptor activity-modifying protein 1, CRLR activity-modifying protein 1 |
5 | water | water | 18.0 | 95 | Chemie (HOH) |
Sequence modifications
C, c: 23 - 133 (UniProt: Q16602)
R, r: 26 - 117 (UniProt: O60894)
PDB | External Database | Details |
---|---|---|
Met -5 | - | expression tag |
Ser -4 | - | expression tag |
Tyr -3 | - | expression tag |
Tyr -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
His 2 | - | expression tag |
His 3 | - | expression tag |
His 4 | - | expression tag |
Leu 5 | - | expression tag |
Glu 6 | - | expression tag |
Ser 7 | - | expression tag |
Thr 8 | - | expression tag |
Ser 9 | - | expression tag |
Leu 10 | - | expression tag |
Tyr 11 | - | expression tag |
Lys 12 | - | expression tag |
Lys 13 | - | expression tag |
Ala 14 | - | expression tag |
Gly 15 | - | expression tag |
Ser 16 | - | expression tag |
Leu 17 | - | expression tag |
Val 18 | - | expression tag |
Pro 19 | - | expression tag |
Arg 20 | - | expression tag |
Gly 21 | - | expression tag |
Ser 22 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -2 | - | expression tag |
Ser -1 | - | expression tag |
Tyr 0 | - | expression tag |
Tyr 1 | - | expression tag |
His 2 | - | expression tag |
His 3 | - | expression tag |
His 4 | - | expression tag |
His 5 | - | expression tag |
His 6 | - | expression tag |
His 7 | - | expression tag |
Leu 8 | - | expression tag |
Glu 9 | - | expression tag |
Ser 10 | - | expression tag |
Thr 11 | - | expression tag |
Ser 12 | - | expression tag |
Leu 13 | - | expression tag |
Tyr 14 | - | expression tag |
Lys 15 | - | expression tag |
Lys 16 | - | expression tag |
Ala 17 | - | expression tag |
Gly 18 | - | expression tag |
Ser 19 | - | expression tag |
Leu 20 | - | expression tag |
Val 21 | - | expression tag |
Pro 22 | - | expression tag |
Arg 23 | - | expression tag |
Gly 24 | - | expression tag |
Ser 25 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 156842.8 | |
All* | Total formula weight | 156842.8 |