6UMG

Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (H, h)	erenumab Fab heavy chain, IgG1	polymer	237	25483.5	2		Homo sapiens (Human)
2	B, F (L, l)	erenumab Fab light chain, IgG1	polymer	216	22827.3	2		Homo sapiens (Human)
3	C, G (C, c)	Calcitonin gene-related peptide type 1 receptor	polymer	139	16269.9	2	UniProt (Q16602) Pfam (PF02793)	Homo sapiens (Human)	CGRP type 1 receptor, Calcitonin receptor-like receptor
4	D, H (R, r)	Receptor activity-modifying protein 1	polymer	120	13840.7	2	UniProt (O60894) Pfam (PF04901)	Homo sapiens (Human)	Calcitonin-receptor-like receptor activity-modifying protein 1, CRLR activity-modifying protein 1
5	I, J, K, L, M... (H, L, C, R, h...)	water	water		18.0	95	Chemie (HOH)

Sequence modifications

C, c: 23 - 133 (UniProt: Q16602)

PDB	External Database	Details
Met -5	-	expression tag
Ser -4	-	expression tag
Tyr -3	-	expression tag
Tyr -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
Leu 5	-	expression tag
Glu 6	-	expression tag
Ser 7	-	expression tag
Thr 8	-	expression tag
Ser 9	-	expression tag
Leu 10	-	expression tag
Tyr 11	-	expression tag
Lys 12	-	expression tag
Lys 13	-	expression tag
Ala 14	-	expression tag
Gly 15	-	expression tag
Ser 16	-	expression tag
Leu 17	-	expression tag
Val 18	-	expression tag
Pro 19	-	expression tag
Arg 20	-	expression tag
Gly 21	-	expression tag
Ser 22	-	expression tag

R, r: 26 - 117 (UniProt: O60894)

PDB	External Database	Details
Met -2	-	expression tag
Ser -1	-	expression tag
Tyr 0	-	expression tag
Tyr 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
Leu 8	-	expression tag
Glu 9	-	expression tag
Ser 10	-	expression tag
Thr 11	-	expression tag
Ser 12	-	expression tag
Leu 13	-	expression tag
Tyr 14	-	expression tag
Lys 15	-	expression tag
Lys 16	-	expression tag
Ala 17	-	expression tag
Gly 18	-	expression tag
Ser 19	-	expression tag
Leu 20	-	expression tag
Val 21	-	expression tag
Pro 22	-	expression tag
Arg 23	-	expression tag
Gly 24	-	expression tag
Ser 25	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	156842.8
All*	Total formula weight	156842.8

*Water molecules are not included.