3BUX
| Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met | 分子名称: | 13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL | 著者 | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | 登録日 | 2008-01-03 | 公開日 | 2008-02-26 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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3BUM
| Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2 | 分子名称: | E3 ubiquitin-protein ligase CBL, Protein sprouty homolog 2 | 著者 | Ng, C, Jackson, A.R, Buschdorf, P.J, Sun, Q, Guy, R.G, Sivaraman, J. | 登録日 | 2008-01-03 | 公開日 | 2008-02-26 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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3BUW
| Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk | 分子名称: | 13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL | 著者 | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | 登録日 | 2008-01-03 | 公開日 | 2008-02-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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6P9E
| Crystal structure of IL-36gamma complexed to A-552 | 分子名称: | (2S)-2-{[4-(3-amino-4-methylphenyl)-6-methylpyrimidin-2-yl]oxy}-3-methoxy-3,3-diphenylpropanoic acid, Interleukin-36 gamma | 著者 | Argiriadi, M.A, Todorovic, T, Su, Z, Putman, B, Kakavas, S.J, Salte, K.M, McDonald, H.A, Wetter, J.B, Paulsboe, S.E, Sun, Q, Gerstein, C.E, Medina, L, Sielaff, B, Sadhukhan, R, Stockmann, H, Richardson, P.L, Qiu, W, Henry, R.F, Herold, J.M, Shotwell, J.B, McGaraughty, S.P, Honore, P, Gopalakrishnan, S.M, Sun, C.C, Scott, V.E. | 登録日 | 2019-06-10 | 公開日 | 2019-06-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Small Molecule IL-36 gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis. Sci Rep, 9, 2019
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4WCW
| Ribosomal silencing factor during starvation or stationary phase (RsfS) from Mycobacterium tuberculosis | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, Ribosomal silencing factor RsfS | 著者 | Li, X, Sun, Q, Jiang, C, Yang, K, Hung, L, Zhang, J, Sacchettini, J, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2014-09-05 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome. Structure, 23, 2015
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3BUO
| Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor' | 分子名称: | 13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL | 著者 | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | 登録日 | 2008-01-03 | 公開日 | 2008-02-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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1R0E
| Glycogen synthase kinase-3 beta in complex with 3-indolyl-4-arylmaleimide inhibitor | 分子名称: | 3-[3-(2,3-DIHYDROXY-PROPYLAMINO)-PHENYL]-4-(5-FLUORO-1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE, CITRATE ANION, Glycogen synthase kinase-3 beta | 著者 | Allard, J, Nikolcheva, T, Gong, L, Wang, J, Dunten, P, Avnur, Z, Waters, R, Sun, Q, Skinner, B. | 登録日 | 2003-09-20 | 公開日 | 2004-10-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | From genetics to therapeutics: the Wnt pathway and osteoporosis To be Published
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8K4F
| DHODH in complex with compound A0 | 分子名称: | 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine, 6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione, ACETATE ION, ... | 著者 | Jian, L, Sun, Q. | 登録日 | 2023-07-18 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Discovery and Optimization of Novel h DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease. J.Med.Chem., 66, 2023
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8JYW
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8JYZ
| Cryo-EM structure of RCD-1 pore from Neurospora crassa | 分子名称: | Gasdermin-like protein rcd-1-1, Gasdermin-like protein rcd-1-2 | 著者 | Hou, Y.J, Sun, Q, Li, Y, Ding, J. | 登録日 | 2023-07-04 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | 主引用文献 | Cleavage-independent activation of ancient eukaryotic gasdermins and structural mechanisms. Science, 384, 2024
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3SAD
| Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-mehtylphenyl)-2,4-dioxobutanoic acid inhibitor | 分子名称: | 4-(2-methylphenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G | 著者 | Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | 登録日 | 2011-06-02 | 公開日 | 2012-11-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
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3SAZ
| Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(3-bromophenyl)-2,4-dioxobutanoic acid inhibitor | 分子名称: | 4-(3-bromophenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G | 著者 | Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | 登録日 | 2011-06-03 | 公開日 | 2012-11-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
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3SB0
| Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid inhibitor | 分子名称: | 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G | 著者 | Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | 登録日 | 2011-06-03 | 公開日 | 2012-11-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.199 Å) | 主引用文献 | Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
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3S9I
| Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-4-dioxo-4-phenylbutanoic acid inhibitor | 分子名称: | 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MAGNESIUM ION, Malate synthase G | 著者 | Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | 登録日 | 2011-06-01 | 公開日 | 2012-11-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
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3S9Z
| Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-bromophenyl)-2,4-dioxobutanoic acid inhibitor | 分子名称: | 4-(2-bromophenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G | 著者 | Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | 登録日 | 2011-06-02 | 公開日 | 2012-11-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.793 Å) | 主引用文献 | Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
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7XPI
| Structure of a oxidoreductase | 分子名称: | Apoptosis inducing factor mitochondria associated 2, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Lv, Y, Sun, Q, Wang, Q, Zhu, D. | 登録日 | 2022-05-04 | 公開日 | 2023-06-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural insights into FSP1 catalysis and ferroptosis inhibition. Nat Commun, 14, 2023
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7YTL
| Structure of a oxidoreductase in complex with quinone | 分子名称: | Apoptosis inducing factor mitochondria associated 2, FLAVIN-ADENINE DINUCLEOTIDE, UBIQUINONE-1 | 著者 | Lv, Y, Sun, Q, Wang, Q, Zhu, D. | 登録日 | 2022-08-15 | 公開日 | 2023-08-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Structural insights into FSP1 catalysis and ferroptosis inhibition. Nat Commun, 14, 2023
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4NYI
| Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | 分子名称: | GTPase HRas, MAGNESIUM ION, N-{1-[(5-methyl-1H-indol-3-yl)methyl]piperidin-4-yl}-L-tryptophanamide, ... | 著者 | Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. | 登録日 | 2013-12-10 | 公開日 | 2014-03-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.9612 Å) | 主引用文献 | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc.Natl.Acad.Sci.USA, 111, 2014
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4OWT
| Structural basis of SOSS1 complex assembly | 分子名称: | Integrator complex subunit 3, SOSS complex subunit B1, SOSS complex subunit C | 著者 | Ren, W, Sun, Q, Tang, X, Song, H. | 登録日 | 2014-02-03 | 公開日 | 2014-04-16 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA. Cell Rep, 6, 2014
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4OWX
| Structural basis of SOSS1 in complex with a 12nt ssDNA | 分子名称: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Integrator complex subunit 3, SOSS complex subunit B1 | 著者 | Ren, W, Sun, Q, Tang, X, Song, H. | 登録日 | 2014-02-04 | 公開日 | 2014-04-16 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA. Cell Rep, 6, 2014
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4NYM
| Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | 分子名称: | GTPase HRas, MAGNESIUM ION, N-[1-(1H-indol-3-ylmethyl)piperidin-4-yl]-L-tryptophanamide, ... | 著者 | Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. | 登録日 | 2013-12-10 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.5529 Å) | 主引用文献 | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc.Natl.Acad.Sci.USA, 111, 2014
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4NYJ
| Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | 分子名称: | GTPase HRas, MAGNESIUM ION, N-[1-(1H-indol-3-ylmethyl)piperidin-4-yl]glycinamide, ... | 著者 | Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. | 登録日 | 2013-12-10 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8522 Å) | 主引用文献 | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc.Natl.Acad.Sci.USA, 111, 2014
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4OWW
| Structural basis of SOSS1 in complex with a 35nt ssDNA | 分子名称: | DNA (5'-D(P*TP*TP*TP*TP*TP*T)-3'), Integrator complex subunit 3, SOSS complex subunit B1, ... | 著者 | Ren, W, Sun, Q, Tang, X, Song, H. | 登録日 | 2014-02-04 | 公開日 | 2014-04-16 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA. Cell Rep, 6, 2014
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7XLT
| Cryo-EM Structure of R-loop monoclonal antibody S9.6 in recognizing RNA:DNA hybrids | 分子名称: | DNA, RNA, S9.6 Fab HC, ... | 著者 | Li, Q, Lin, C, Luo, Z, Li, H, Li, X, Sun, Q. | 登録日 | 2022-04-22 | 公開日 | 2022-05-25 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Cryo-EM structure of R-loop monoclonal antibody S9.6 in recognizing RNA:DNA hybrids. J Genet Genomics, 49, 2022
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7UAD
| Crystal structure of human PTPN2 with inhibitor ABBV-CLS-484 | 分子名称: | 5-{(7R)-1-fluoro-3-hydroxy-7-[(3-methylbutyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl}-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, Tyrosine-protein phosphatase non-receptor type 2 | 著者 | Longenecker, K.L, Qiu, W, Sun, Q, Frost, J.M. | 登録日 | 2022-03-12 | 公開日 | 2023-07-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.044 Å) | 主引用文献 | The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature, 622, 2023
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