1KGT
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![BU of 1kgt by Molmil](/molmil-images/mine/1kgt) | Crystal Structure of Tetrahydrodipicolinate N-Succinyltransferase in Complex with Pimelate and Succinyl-CoA | 分子名称: | 2,3,4,5-TETRAHYDROPYRIDINE-2-CARBOXYLATE N-SUCCINYLTRANSFERASE, PIMELIC ACID, SUCCINYL-COENZYME A | 著者 | Beaman, T.W, Vogel, K.W, Drueckhammer, D.G, Blanchard, J.S, Roderick, S.L. | 登録日 | 2001-11-28 | 公開日 | 2002-04-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Acyl group specificity at the active site of tetrahydridipicolinate N-succinyltransferase. Protein Sci., 11, 2002
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3DWZ
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![BU of 3dwz by Molmil](/molmil-images/mine/3dwz) | Meropenem Covalent Adduct with TB Beta-lactamase | 分子名称: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Tremblay, L.W, Hugonnet, J.E, Blanchard, J.S. | 登録日 | 2008-07-23 | 公開日 | 2009-03-10 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis Science, 323, 2009
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5U3F
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![BU of 5u3f by Molmil](/molmil-images/mine/5u3f) | Structure of Mycobacterium tuberculosis IlvE, a branched-chain amino acid transaminase, in complex with D-cycloserine derivative | 分子名称: | (5-hydroxy-6-methyl-4-{[(3-oxo-2,3-dihydro-1,2-oxazol-4-yl)amino]methyl}pyridin-3-yl)methyl dihydrogen phosphate, Branched-chain-amino-acid aminotransferase | 著者 | Favrot, L, Amorim Franco, T.M, Blanchard, J.S. | 登録日 | 2016-12-02 | 公開日 | 2017-03-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.695 Å) | 主引用文献 | Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine. ACS Chem. Biol., 12, 2017
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2J8K
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![BU of 2j8k by Molmil](/molmil-images/mine/2j8k) | Structure of the fusion of NP275 and NP276, pentapeptide repeat proteins from Nostoc punctiforme | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, NP275-NP276, SULFATE ION | 著者 | Vetting, M.W, Hegde, S.S, Hazleton, K.Z, Blanchard, J.S. | 登録日 | 2006-10-25 | 公開日 | 2006-12-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural Characterization of the Fusion of Two Pentapeptide Repeat Proteins, Np275 and Np276, from Nostoc Punctiforme: Resurrection of an Ancestral Protein. Protein Sci., 16, 2007
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2J8I
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![BU of 2j8i by Molmil](/molmil-images/mine/2j8i) | Structure of NP275, a pentapeptide repeat protein from Nostoc punctiforme | 分子名称: | CHLORIDE ION, NP275 | 著者 | Vetting, M.W, Hegde, S.S, Hazleton, K.Z, Blanchard, J.S. | 登録日 | 2006-10-25 | 公開日 | 2006-12-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Characterization of the Fusion of Two Pentapeptide Repeat Proteins, Np275 and Np276, from Nostoc Punctiforme: Resurrection of an Ancestral Protein. Protein Sci., 16, 2007
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2JEV
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![BU of 2jev by Molmil](/molmil-images/mine/2jev) | Crystal structure of human spermine,spermidine acetyltransferase in complex with a bisubstrate analog (N1-acetylspermine-S-CoA). | 分子名称: | (3R)-27-AMINO-3-HYDROXY-2,2-DIMETHYL-4,8,14-TRIOXO-12-THIA-5,9,15,19,24-PENTAAZAHEPTACOS-1-YL [(2S,3R,4S,5S)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, DIAMINE ACETYLTRANSFERASE 1 | 著者 | Hegde, S.S, Chandler, J, Vetting, M.W, Yu, M, Blanchard, J.S. | 登録日 | 2007-01-23 | 公開日 | 2007-06-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Mechanistic and Structural Analysis of Human Spermidine/Spermine N(1)-Acetyltransferase. Biochemistry, 46, 2007
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2GKE
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![BU of 2gke by Molmil](/molmil-images/mine/2gke) | Crystal structure of diaminopimelate epimerase in complex with an irreversible inhibitor LL-AziDAP | 分子名称: | (2S,6S)-2,6-DIAMINO-2-METHYLHEPTANEDIOIC ACID, ACETIC ACID, Diaminopimelate epimerase, ... | 著者 | Pillai, B, Cherney, M.M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C, James, M.N. | 登録日 | 2006-04-01 | 公開日 | 2006-05-16 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2GKJ
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![BU of 2gkj by Molmil](/molmil-images/mine/2gkj) | Crystal structure of diaminopimelate epimerase in complex with an irreversible inhibitor DL-AZIDAP | 分子名称: | (2R,6S)-2,6-DIAMINO-2-METHYLHEPTANEDIOIC ACID, ACETIC ACID, Diaminopimelate epimerase | 著者 | Pillai, B, Cherney, M.M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C, James, M.N. | 登録日 | 2006-04-02 | 公開日 | 2006-05-16 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target. Proc.Natl.Acad.Sci.Usa, 103, 2006
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1BWZ
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![BU of 1bwz by Molmil](/molmil-images/mine/1bwz) | |
1C3V
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![BU of 1c3v by Molmil](/molmil-images/mine/1c3v) | DIHYDRODIPICOLINATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND PDC | 分子名称: | DIHYDRODIPICOLINATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PYRIDINE-2,6-DICARBOXYLIC ACID, ... | 著者 | Cirilli, M, Zheng, R, Scapin, G, Blanchard, J.S, TB Structural Genomics Consortium (TBSGC) | 登録日 | 1999-07-28 | 公開日 | 2003-08-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | The three-dimensional structures of the Mycobacterium tuberculosis
dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes.
Structural and mutagenic analysis of relaxed nucleotide specificity Biochemistry, 42, 2003
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2PR2
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![BU of 2pr2 by Molmil](/molmil-images/mine/2pr2) | |
2Q9J
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![BU of 2q9j by Molmil](/molmil-images/mine/2q9j) | Crystal structure of the C217S mutant of diaminopimelate epimerase | 分子名称: | 1,2-ETHANEDIOL, Diaminopimelate epimerase, SULFATE ION | 著者 | Pillai, B, Cherney, M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C. | 登録日 | 2007-06-12 | 公開日 | 2007-10-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase. Biochem.Biophys.Res.Commun., 363, 2007
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2Q9H
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![BU of 2q9h by Molmil](/molmil-images/mine/2q9h) | Crystal structure of the C73S mutant of diaminopimelate epimerase | 分子名称: | ACETIC ACID, Diaminopimelate epimerase, L(+)-TARTARIC ACID | 著者 | Pillai, B, Cherney, M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C, James, M.N.G. | 登録日 | 2007-06-12 | 公開日 | 2007-10-23 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase. Biochem.Biophys.Res.Commun., 363, 2007
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1ENY
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![BU of 1eny by Molmil](/molmil-images/mine/1eny) | CRYSTAL STRUCTURE AND FUNCTION OF THE ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS | 分子名称: | ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Dessen, A, Quemard, A, Blanchard, J.S, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 1995-01-27 | 公開日 | 1996-01-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis. Science, 267, 1995
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1ENZ
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![BU of 1enz by Molmil](/molmil-images/mine/1enz) | CRYSTAL STRUCTURE AND FUNCTION OF THE ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS | 分子名称: | ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Dessen, A, Quemard, A, Blanchard, J.S, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 1995-01-27 | 公開日 | 1996-01-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis. Science, 267, 1995
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4DF6
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![BU of 4df6 by Molmil](/molmil-images/mine/4df6) | |
4JLF
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![BU of 4jlf by Molmil](/molmil-images/mine/4jlf) | Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase | 分子名称: | Beta-lactamase, PHOSPHATE ION | 著者 | Hazra, S, Kurz, S, Blanchard, J, Bonomo, R. | 登録日 | 2013-03-12 | 公開日 | 2013-10-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations. Antimicrob.Agents Chemother., 57, 2013
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4HCX
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![BU of 4hcx by Molmil](/molmil-images/mine/4hcx) | |
1S3Z
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![BU of 1s3z by Molmil](/molmil-images/mine/1s3z) | Aminoglycoside N-Acetyltransferase AAC(6')-Iy in Complex with CoA and Ribostamycin | 分子名称: | COENZYME A, NICKEL (II) ION, RIBOSTAMYCIN, ... | 著者 | Vetting, M.W, Magnet, S, Nieves, E, Roderick, S.L, Blachard, J.S. | 登録日 | 2004-01-14 | 公開日 | 2004-05-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones Chem.Biol., 11, 2004
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4X6T
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![BU of 4x6t by Molmil](/molmil-images/mine/4x6t) | M.tuberculosis betalactamase complexed with inhibitor EC19 | 分子名称: | 3-[(2R)-2-(dihydroxyboranyl)-2-{[(2R)-2-{[(4-ethyl-2,3-dioxo-3,4-dihydropyrazin-1(2H)-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}ethyl]benzoic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Hazra, S. | 登録日 | 2014-12-09 | 公開日 | 2015-12-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Inhibiting the beta-Lactamase of Mycobacterium tuberculosis (Mtb) with Novel Boronic Acid Transition-State Inhibitors (BATSIs). ACS Infect Dis, 1, 2015
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4Q8I
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![BU of 4q8i by Molmil](/molmil-images/mine/4q8i) | Crystal Structure of beta-lactamase from M.tuberculosis covalently complexed with Tebipenem | 分子名称: | (4R,5S)-3-(1-(4,5-dihydrothiazol-2-yl)azetidin-3-ylthio)-5-((2S,3R)-3-hydroxy-1-oxobutan-2-yl)-4-methyl-4,5- dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Hazra, S, Blanchard, J. | 登録日 | 2014-04-27 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the beta-lactamase from Mycobacterium tuberculosis. Biochemistry, 53, 2014
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4QHC
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![BU of 4qhc by Molmil](/molmil-images/mine/4qhc) | Structure of M.Tuberculosis Betalactamase (Blac) with inhibitor having novel mechanism | 分子名称: | (3R,6R,7S)-7-[(2R,3aR)-hexahydropyrazolo[1,5-c][1,3]thiazin-2-yl]-6-(hydroxymethyl)-1,4-thiazepane-3-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Hazra, S, Blanchard, J. | 登録日 | 2014-05-28 | 公開日 | 2015-07-22 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.899 Å) | 主引用文献 | Kinetic and Structural Characterization of the Interaction of 6-Methylidene Penem 2 with the beta-Lactamase from Mycobacterium tuberculosis. Biochemistry, 54, 2015
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4QB8
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![BU of 4qb8 by Molmil](/molmil-images/mine/4qb8) | |
6OVT
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![BU of 6ovt by Molmil](/molmil-images/mine/6ovt) | Crystal Structure of IlvD from Mycobacterium tuberculosis | 分子名称: | DI(HYDROXYETHYL)ETHER, Dihydroxy-acid dehydratase, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Almo, S.C, Grove, T.L, Bonanno, J.B, Baker, E.N, Bashiri, G. | 登録日 | 2019-05-08 | 公開日 | 2019-08-07 | 最終更新日 | 2019-12-18 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | The active site of theMycobacterium tuberculosisbranched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster. J.Biol.Chem., 294, 2019
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3M6H
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![BU of 3m6h by Molmil](/molmil-images/mine/3m6h) | Crystal Structure of Post-isomerized Ertapenem Covalent Adduct with TB B-lactamase | 分子名称: | (2S,3R,4S)-4-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-2-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Tremblay, L.W. | 登録日 | 2010-03-15 | 公開日 | 2010-04-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.994 Å) | 主引用文献 | Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem. Biochemistry, 49, 2010
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