4QHC

Structure of M.Tuberculosis Betalactamase (Blac) with inhibitor having novel mechanism

Summary for 4QHC

• Entry DOI: 10.2210/pdb4qhc/pdb
• Related: 4DF6 4Q8I 4QB8
• Descriptor: Beta-lactamase, (3R,6R,7S)-7-[(2R,3aR)-hexahydropyrazolo[1,5-c][1,3]thiazin-2-yl]-6-(hydroxymethyl)-1,4-thiazepane-3-carboxylic acid, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: betalactam, betalactamase, penems, drug resistance, novel mechanism, qm/mm, 3-layer sandwich, dd-peptidase, beta-lactamase super family, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mycobacterium tuberculosis
• Cellular location: Cell inner membrane : P9WKD3
• Total number of polymer chains: 1
• Total formula weight: 28867.21

Authors

Hazra, S.,Blanchard, J. (deposition date: 2014-05-28, release date: 2015-07-22, Last modification date: 2024-02-28)

• Primary citation: Hazra, S.,Kurz, S.G.,Wolff, K.,Nguyen, L.,Bonomo, R.A.,Blanchard, J.S.; Kinetic and Structural Characterization of the Interaction of 6-Methylidene Penem 2 with the beta-Lactamase from Mycobacterium tuberculosis.; Biochemistry, 54:5657-5664, 2015; PubMed: 26237118; DOI: 10.1021/acs.biochem.5b00698

Experimental method

X-RAY DIFFRACTION (1.899 Å)