6KG7
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![BU of 6kg7 by Molmil](/molmil-images/mine/6kg7) | Cryo-EM Structure of the Mammalian Tactile Channel Piezo2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Piezo-type mechanosensitive ion channel component 2 | 著者 | Wang, L, Zhou, H, Zhang, M, Liu, W, Deng, T, Zhao, Q, Li, Y, Lei, J, Li, X, Xiao, B. | 登録日 | 2019-07-11 | 公開日 | 2019-09-04 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure and mechanogating of the mammalian tactile channel PIEZO2. Nature, 573, 2019
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7E1A
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2ICW
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![BU of 2icw by Molmil](/molmil-images/mine/2icw) | Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule | 分子名称: | HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain, ... | 著者 | Wang, L, Zhao, Y, Li, H. | 登録日 | 2006-09-13 | 公開日 | 2007-03-20 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC. Nat.Struct.Mol.Biol., 14, 2007
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7DV5
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2GPU
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![BU of 2gpu by Molmil](/molmil-images/mine/2gpu) | Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen | 分子名称: | 4-HYDROXYTAMOXIFEN, Estrogen-related receptor gamma | 著者 | Wang, L, Zuercher, W.J, Consler, T.G, Lambert, M.H, Miller, A.B, Osband-Miller, L.A, McKee, D.D, Willson, T.M, Nolte, R.T. | 登録日 | 2006-04-18 | 公開日 | 2006-09-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem., 281, 2006
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2GPV
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![BU of 2gpv by Molmil](/molmil-images/mine/2gpv) | Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen and a SMRT peptide | 分子名称: | 4-HYDROXYTAMOXIFEN, Estrogen-related receptor gamma, Nuclear receptor corepressor 2 | 著者 | Wang, L, Zuercher, W.J, Consler, T.G, Lambert, M.H, Miller, A.B, Osband-miller, L.A, McKee, D.D, Willson, T.M, Nolte, R.T. | 登録日 | 2006-04-18 | 公開日 | 2006-09-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem., 281, 2006
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2GPO
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![BU of 2gpo by Molmil](/molmil-images/mine/2gpo) | Estrogen Related Receptor-gamma ligand binding domain complexed with a synthetic peptide from RIP140 | 分子名称: | Estrogen-related receptor gamma, Nuclear receptor-interacting protein 1 | 著者 | Wang, L, Zuercher, W.J, Consler, T.G, Lambert, M.H, Miller, A.B, Osband-miller, L.A, McKee, D.D, Willson, T.M, Nolte, R.T. | 登録日 | 2006-04-18 | 公開日 | 2006-09-26 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem., 281, 2006
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2GP7
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![BU of 2gp7 by Molmil](/molmil-images/mine/2gp7) | Estrogen Related Receptor-gamma ligand binding domain | 分子名称: | CALCIUM ION, Estrogen-related receptor gamma | 著者 | Wang, L, Zuercher, W.J, Consler, T.G, Lambert, M.H, Miller, A.B, Osband-miller, L.A, McKee, D.D, Willson, T.M, Nolte, R.T. | 登録日 | 2006-04-17 | 公開日 | 2006-09-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem., 281, 2006
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2GPP
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![BU of 2gpp by Molmil](/molmil-images/mine/2gpp) | Estrogen Related Receptor-gamma ligand binding domain complexed with a RIP140 peptide and synthetic ligand GSK4716 | 分子名称: | 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE, Estrogen-related receptor gamma, Nuclear receptor-interacting protein 1 | 著者 | Wang, L, Zuercher, W.J, Consler, T.G, Lambert, M.H, Miller, A.B, Osband-miller, L.A, McKee, D.D, Willson, T.M, Nolte, R.T. | 登録日 | 2006-04-18 | 公開日 | 2006-09-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem., 281, 2006
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8UUK
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![BU of 8uuk by Molmil](/molmil-images/mine/8uuk) | Pendrin in apo | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL, Lauryl Maltose Neopentyl Glycol, ... | 著者 | Wang, L, Hoang, A, Zhou, M. | 登録日 | 2023-11-01 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Mechanism of anion exchange and small-molecule inhibition of pendrin. Nat Commun, 15, 2024
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7UPR
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![BU of 7upr by Molmil](/molmil-images/mine/7upr) | Human mitochondrial AAA protein ATAD1 (with a catalytic dead mutation) in complex with a peptide substrate (closed conformation) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Outer mitochondrial transmembrane helix translocase, ... | 著者 | Wang, L, Toutkoushian, H, Belyy, V, Kokontis, C, Walter, P. | 登録日 | 2022-04-16 | 公開日 | 2022-06-15 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Conserved structural elements specialize ATAD1 as a membrane protein extraction machine. Elife, 11, 2022
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7UPT
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![BU of 7upt by Molmil](/molmil-images/mine/7upt) | Human mitochondrial AAA protein ATAD1 (with a catalytic dead mutation) in complex with a peptide substrate (open conformation) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Wang, L, Toutkoushian, H, Belyy, V, Kokontis, C, Walter, P. | 登録日 | 2022-04-16 | 公開日 | 2022-06-15 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Conserved structural elements specialize ATAD1 as a membrane protein extraction machine. Elife, 11, 2022
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7FFT
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7FFW
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![BU of 7ffw by Molmil](/molmil-images/mine/7ffw) | The crystal structure of a domain-swapped dimeric maltodextrin-binding protein MalE from Salmonella enterica | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, METHOXYETHANE, ... | 著者 | Wang, L, Bu, T, Bai, X. | 登録日 | 2021-07-23 | 公開日 | 2021-09-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of the domain-swapped dimeric maltodextrin-binding protein MalE from Salmonella enterica. Acta Crystallogr D Struct Biol, 78, 2022
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7EPU
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![BU of 7epu by Molmil](/molmil-images/mine/7epu) | Crystal structure of HsALC1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chromodomain-helicase-DNA-binding protein 1-like, MAGNESIUM ION, ... | 著者 | Wang, L, Chen, K.J. | 登録日 | 2021-04-27 | 公開日 | 2021-07-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome. Nat Commun, 12, 2021
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7F8E
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4V9C
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![BU of 4v9c by Molmil](/molmil-images/mine/4v9c) | Allosteric control of the ribosome by small-molecule antibiotics | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Cate, J.H.D, Pulk, A, Blanchard, S.C, Wang, L, Feldman, M.B, Wasserman, M.R, Altman, R. | 登録日 | 2012-07-25 | 公開日 | 2014-07-09 | 最終更新日 | 2014-12-10 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Allosteric control of the ribosome by small-molecule antibiotics. Nat.Struct.Mol.Biol., 19, 2012
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3UD6
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![BU of 3ud6 by Molmil](/molmil-images/mine/3ud6) | Structural analyses of covalent enzyme-substrate analogue complexes reveal strengths and limitations of de novo enzyme design | 分子名称: | 1-(6-METHOXYNAPHTHALEN-2-YL)BUTANE-1,3-DIONE, RETRO-ALDOLASE, SULFATE ION | 著者 | Baker, D, Stoddard, B.L, Althoff, E.A, Wang, L, Jiang, L, Moody, J, Bolduc, J, Lassila, J, Hilvert, D. | 登録日 | 2011-10-27 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | 主引用文献 | Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. J.Mol.Biol., 415, 2012
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4U7P
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![BU of 4u7p by Molmil](/molmil-images/mine/4u7p) | Crystal structure of DNMT3A-DNMT3L complex | 分子名称: | DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Wang, L, Guo, X, Li, J, Xiao, J, Yin, X, He, S, Wang, J, Xu, Y. | 登録日 | 2014-07-31 | 公開日 | 2014-11-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.821 Å) | 主引用文献 | Structural insight into autoinhibition and histone H3-induced activation of DNMT3A Nature, 517, 2015
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7RLO
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![BU of 7rlo by Molmil](/molmil-images/mine/7rlo) | Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex with a viral protein NSs | 分子名称: | Non-structural protein NS-S, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | 著者 | Wang, L, Schoof, M, Cogan, J, Lawrence, R, Boone, M, Wuerth, J, Frost, M, Walter, P. | 登録日 | 2021-07-26 | 公開日 | 2021-12-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Commun, 12, 2021
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8GQU
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![BU of 8gqu by Molmil](/molmil-images/mine/8gqu) | AK-42 inhibitor binding human ClC-2 TMD | 分子名称: | 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, Chloride channel protein 2 | 著者 | Wang, L. | 登録日 | 2022-08-30 | 公開日 | 2023-07-05 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42. Nat Commun, 14, 2023
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7YR2
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![BU of 7yr2 by Molmil](/molmil-images/mine/7yr2) | SARS-CoV-2 BA.2.75 S Trimer in complex with ACE2(state1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Wang, L. | 登録日 | 2022-08-08 | 公開日 | 2022-10-19 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022
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7YQU
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![BU of 7yqu by Molmil](/molmil-images/mine/7yqu) | SARS-CoV-2 BA.2.75 S Trimer (3 RBD Down) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Wang, L. | 登録日 | 2022-08-08 | 公開日 | 2022-10-19 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022
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7YQZ
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![BU of 7yqz by Molmil](/molmil-images/mine/7yqz) | SARS-CoV-2 BA.2.75 S Trimer in complex with S309 (state3) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S309 heavy chain, S309 light chain, ... | 著者 | Wang, L. | 登録日 | 2022-08-08 | 公開日 | 2022-10-19 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | 主引用文献 | Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022
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7YR0
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![BU of 7yr0 by Molmil](/molmil-images/mine/7yr0) | |