5AVA
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5A7C
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![BU of 5a7c by Molmil](/molmil-images/mine/5a7c) | Crystal structure of the second bromodomain of human BRD3 in complex with compound | 分子名称: | 1,2-ETHANEDIOL, BROMODOMAIN-CONTAINING PROTEIN 3, N-(6-ACETAMIDOHEXYL)ACETAMIDE | 著者 | Welin, M, Kimbung, R, Diehl, C, Hakansson, M, Logan, D.T, Walse, B. | 登録日 | 2015-07-03 | 公開日 | 2016-03-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Cancer Differentiating Agent Hexamethylene Bisacetamide Inhibits Bet Bromodomain Proteins. Cancer Res., 76, 2016
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6IZW
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![BU of 6izw by Molmil](/molmil-images/mine/6izw) | Myxococcus xanthus MglA bound to GTP-gamma-S and MglB | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Gliding motility protein MglB, MAGNESIUM ION, ... | 著者 | Baranwal, J, Gayathri, P. | 登録日 | 2018-12-20 | 公開日 | 2019-10-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Allosteric regulation of a prokaryotic small Ras-like GTPase contributes to cell polarity oscillations in bacterial motility. Plos Biol., 17, 2019
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8FIS
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3SM0
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![BU of 3sm0 by Molmil](/molmil-images/mine/3sm0) | tRNA-Guanine Transglycosylase in complex with lin-Benzohypoxanthine Inhibitor | 分子名称: | 4-{2-[(cyclopentylmethyl)amino]ethyl}-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Klebe, G, Immekus, F, Heine, A. | 登録日 | 2011-06-27 | 公開日 | 2012-06-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | From lin-Benzoguanines to lin-Benzohypoxanthines as Ligands for Zymomonas mobilis tRNA-Guanine Transglycosylase: Replacement of Protein-Ligand Hydrogen Bonding by Importing Water Clusters. Chemistry, 18, 2012
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1WSO
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![BU of 1wso by Molmil](/molmil-images/mine/1wso) | The solution structures of human Orexin-A | 分子名称: | Orexin-A | 著者 | Ikegami, T, Takai, T. | 登録日 | 2004-11-08 | 公開日 | 2004-11-30 | 最終更新日 | 2019-12-25 | 実験手法 | SOLUTION NMR | 主引用文献 | Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor J.Pept.Sci., 12, 2006
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7ZQX
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![BU of 7zqx by Molmil](/molmil-images/mine/7zqx) | Human galectin-3c in complex with a galactose derivative | 分子名称: | (2~{R},3~{R},4~{S},5~{R},6~{R})-2-(5-bromanylpyridin-3-yl)sulfanyl-6-(hydroxymethyl)-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol, CHLORIDE ION, GLYCEROL, ... | 著者 | Zetterberg, F, Nilsson, U.J, Hakansson, M, Logan, D.T. | 登録日 | 2022-05-03 | 公開日 | 2022-11-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease. J.Med.Chem., 65, 2022
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3S1G
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![BU of 3s1g by Molmil](/molmil-images/mine/3s1g) | tRNA-Guanine Transglycosylase in complex with lin-Benzohypoxanthine Inhibitor | 分子名称: | 2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Klebe, G, Immekus, F, Heine, A. | 登録日 | 2011-05-15 | 公開日 | 2012-05-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | From lin-Benzoguanines to lin-Benzohypoxanthines as Ligands for Zymomonas mobilis tRNA-Guanine Transglycosylase: Replacement of Protein-Ligand Hydrogen Bonding by Importing Water Clusters. Chemistry, 18, 2012
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3TLL
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![BU of 3tll by Molmil](/molmil-images/mine/3tll) | tRNA-Guanine Transglycosylase in complex with N-Ethyl-lin-benzoguanine Inhibitor | 分子名称: | 6-(ethylamino)-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Klebe, G, Immekus, F, Heine, A. | 登録日 | 2011-08-30 | 公開日 | 2012-07-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | From lin-Benzoguanines to lin-Benzohypoxanthines as Ligands for Zymomonas mobilis tRNA-Guanine Transglycosylase: Replacement of Protein-Ligand Hydrogen Bonding by Importing Water Clusters. Chemistry, 18, 2012
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2DGB
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2E67
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5ODY
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![BU of 5ody by Molmil](/molmil-images/mine/5ody) | Galectin-3C in complex with dithiogalactoside derivative | 分子名称: | 5,6-bis(fluoranyl)-3-[[(2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,5-bis(oxidanyl)-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-2-yl]sulfanyl-3,5-bis(oxidanyl)oxan-4-yl]oxymethyl]chromen-2-one, Galectin-3 | 著者 | Kumar, R, Peterson, K, Nilsson, U.J, Logan, D.T. | 登録日 | 2017-07-07 | 公開日 | 2018-05-23 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.149 Å) | 主引用文献 | Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity. J. Med. Chem., 61, 2018
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4AD7
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![BU of 4ad7 by Molmil](/molmil-images/mine/4ad7) | Crystal structure of full-length N-glycosylated human glypican-1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYPICAN-1 | 著者 | Svensson, G, Awad, W, Mani, K, Logan, D.T. | 登録日 | 2011-12-22 | 公開日 | 2012-03-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.945 Å) | 主引用文献 | Crystal Structure of N-Glycosylated Human Glypican-1 Core Protein: Structure of Two Loops Evolutionarily Conserved in Vertebrate Glypican-1. J.Biol.Chem., 287, 2012
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4ACR
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![BU of 4acr by Molmil](/molmil-images/mine/4acr) | Crystal structure of N-glycosylated, C-terminally truncated human glypican-1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYPICAN-1 | 著者 | Svensson, G, Awad, W, Mani, K, Logan, D.T. | 登録日 | 2011-12-17 | 公開日 | 2012-02-22 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Crystal Structure of N-Glycosylated Human Glypican-1 Core Protein: Structure of Two Loops Evolutionarily Conserved in Vertebrate Glypican-1. J.Biol.Chem., 287, 2012
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4YWT
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6HHU
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6IIW
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5C0R
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![BU of 5c0r by Molmil](/molmil-images/mine/5c0r) | Crystal Structure of a Generation 3 Influenza Hemagglutinin Stabilized Stem Complexed with the Broadly Neutralizing Antibody C179 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C179 Fab heavy chain, ... | 著者 | Boyington, J.C, kwong, P.D, Nabel, G.J, Mascola, J.R. | 登録日 | 2015-06-12 | 公開日 | 2015-09-02 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.188 Å) | 主引用文献 | Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection. Nat. Med., 21, 2015
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7E50
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![BU of 7e50 by Molmil](/molmil-images/mine/7e50) | Crystal structure of human microplasmin in complex with kazal-type inhibitor AaTI | 分子名称: | AAEL006007-PA, GLYCEROL, Plasminogen, ... | 著者 | Varsha, A.W, Jobichen, C, Mok, Y.K. | 登録日 | 2021-02-16 | 公開日 | 2022-02-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of Aedes aegypti trypsin inhibitor in complex with mu-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor. Protein Sci., 31, 2022
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5DH5
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![BU of 5dh5 by Molmil](/molmil-images/mine/5dh5) | PDE10 complexed with N-[(1-methylpyrazol-4-yl)methyl]-5-[[(1S,2S)-2-(2-pyridyl)cyclopropyl]methoxy]pyrazolo[1,5-a]pyrimidin-7-amine | 分子名称: | MAGNESIUM ION, N-[(1-methyl-1H-pyrazol-4-yl)methyl]-5-{[(1S,2S)-2-(pyridin-2-yl)cyclopropyl]methoxy}pyrazolo[1,5-a]pyrimidin-7-amine, ZINC ION, ... | 著者 | Yan, Y. | 登録日 | 2015-08-29 | 公開日 | 2016-01-27 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg.Med.Chem.Lett., 26, 2016
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2CB1
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![BU of 2cb1 by Molmil](/molmil-images/mine/2cb1) | Crystal Structure of O-actetyl Homoserine Sulfhydrylase From Thermus Thermophilus HB8,OAH2. | 分子名称: | O-ACETYL HOMOSERINE SULFHYDRYLASE, PYRIDOXAL-5'-PHOSPHATE | 著者 | Imagawa, T, Utsunomiya, H, Tsuge, H, Ebihara, A, Kanagawa, M, Nakagawa, N, Kuroishi, C, Agari, Y, Kuramitsu, S, Yokoyama, S. | 登録日 | 2005-12-28 | 公開日 | 2007-01-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Crystal Structure of O-Acetyl Homoserine Sulfhydrylase To be Published
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5DH4
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![BU of 5dh4 by Molmil](/molmil-images/mine/5dh4) | PDE10 complexed with 5-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine | 分子名称: | 3-(1-hydroxy-2-methylpropan-2-yl)-5-phenyl-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione, 5-chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine, MAGNESIUM ION, ... | 著者 | Yan, Y. | 登録日 | 2015-08-29 | 公開日 | 2016-01-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg.Med.Chem.Lett., 26, 2016
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4BWE
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![BU of 4bwe by Molmil](/molmil-images/mine/4bwe) | Crystal structure of C-terminally truncated glypican-1 after controlled dehydration to 86 percent relative humidity | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Glypican-1 | 著者 | Awad, W, Svensson Birkedal, G, Thunnissen, M.M.G.M, Mani, K, Logan, D.T. | 登録日 | 2013-07-01 | 公開日 | 2013-12-18 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Improvements in the order, isotropy and electron density of glypican-1 crystals by controlled dehydration. Acta Crystallogr. D Biol. Crystallogr., 69, 2013
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5C0S
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![BU of 5c0s by Molmil](/molmil-images/mine/5c0s) | Crystal structure of a generation 4 influenza hemagglutinin stabilized stem in complex with the broadly neutralizing antibody CR6261 | 分子名称: | CR6261 antibody heavy chain, CR6261 antibody light chain, Hemagglutinin, ... | 著者 | Boyington, J.C, Kwong, P.D, Nabel, G.J, Mascola, J.R. | 登録日 | 2015-06-12 | 公開日 | 2015-09-02 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection. Nat. Med., 21, 2015
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7KNA
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![BU of 7kna by Molmil](/molmil-images/mine/7kna) | Localized reconstruction of the H1 A/Michigan/45/2015 ectodomain displayed at the surface of I53_dn5 nanoparticle | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin,I53_dn5 | 著者 | Acton, O.J, Park, Y.J, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2020-11-04 | 公開日 | 2021-03-31 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Quadrivalent influenza nanoparticle vaccines induce broad protection. Nature, 592, 2021
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