5A7C

Crystal structure of the second bromodomain of human BRD3 in complex with compound

Summary for 5A7C

• Entry DOI: 10.2210/pdb5a7c/pdb
• Related: 5A6N 5A6O
• Descriptor: BROMODOMAIN-CONTAINING PROTEIN 3, N-(6-ACETAMIDOHEXYL)ACETAMIDE, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: dna binding protein, brd3, bromodomain containing protein 3, ring3-like protein, brd3 domain 2
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus : Q15059
• Total number of polymer chains: 4
• Total formula weight: 54341.05

Authors

Welin, M.,Kimbung, R.,Diehl, C.,Hakansson, M.,Logan, D.T.,Walse, B. (deposition date: 2015-07-03, release date: 2016-03-16, Last modification date: 2024-01-10)

• Primary citation: Nilsson, L.M.,Green, L.C.,Muralidharan, S.V.,Demir, D.,Welin, M.,Bhadury, J.,Logan, D.T.,Walse, B.,Nilsson, J.A.; Cancer Differentiating Agent Hexamethylene Bisacetamide Inhibits Bet Bromodomain Proteins.; Cancer Res., 76:2376-, 2016; PubMed: 26941288; DOI: 10.1158/0008-5472.CAN-15-2721

Experimental method

X-RAY DIFFRACTION (1.9 Å)