5DH5
PDE10 complexed with N-[(1-methylpyrazol-4-yl)methyl]-5-[[(1S,2S)-2-(2-pyridyl)cyclopropyl]methoxy]pyrazolo[1,5-a]pyrimidin-7-amine
Summary for 5DH5
Entry DOI | 10.2210/pdb5dh5/pdb |
Related | 5DH4 |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 80143.14 |
Authors | |
Primary citation | Raheem, I.T.,Schreier, J.D.,Fuerst, J.,Gantert, L.,Hostetler, E.D.,Huszar, S.,Joshi, A.,Kandebo, M.,Kim, S.H.,Li, J.,Ma, B.,McGaughey, G.,Sharma, S.,Shipe, W.D.,Uslaner, J.,Vandeveer, G.H.,Yan, Y.,Renger, J.J.,Smith, S.M.,Coleman, P.J.,Cox, C.D. Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg.Med.Chem.Lett., 26:126-132, 2016 Cited by PubMed: 26602277DOI: 10.1016/j.bmcl.2015.11.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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