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5DH5

PDE10 complexed with N-[(1-methylpyrazol-4-yl)methyl]-5-[[(1S,2S)-2-(2-pyridyl)cyclopropyl]methoxy]pyrazolo[1,5-a]pyrimidin-7-amine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue ZN A 801
ChainResidue
AHIS519
AHIS553
AASP554
AASP664
AHOH902
AHOH911

site_idAC2
Number of Residues6
Detailsbinding site for residue MG A 802
ChainResidue
AHOH937
AHOH955
AHOH966
AASP554
AHOH909
AHOH911

site_idAC3
Number of Residues17
Detailsbinding site for residue 5AY A 803
ChainResidue
AHIS515
ALEU665
ASER667
AVAL668
AILE682
ATYR683
APHE686
AMET703
AGLY715
AGLN716
APHE719
AHOH904
AHOH918
AHOH922
AHOH948
BLYS695
BLEU696

site_idAC4
Number of Residues6
Detailsbinding site for residue ZN B 801
ChainResidue
BHIS519
BHIS553
BASP554
BASP664
BHOH916
BHOH931

site_idAC5
Number of Residues6
Detailsbinding site for residue MG B 802
ChainResidue
BASP554
BHOH901
BHOH907
BHOH916
BHOH939
BHOH956

site_idAC6
Number of Residues17
Detailsbinding site for residue 5AY B 803
ChainResidue
ASER766
ASER767
APRO768
BHIS515
BLEU665
BSER667
BVAL668
BILE682
BTYR683
BPHE686
BMET703
BGLY715
BGLN716
BPHE719
BHOH905
BHOH920
BHOH936

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY
ChainResidueDetails
AHIS553-TYR564

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF
ChainResidueDetails
AASN562
ASER606
AGLN640
AMET659
BASN562
BSER606
BGLN640
BMET659

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PDB entries from 2024-07-17

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