3GWB
| Crystal structure of peptidase M16 inactive domain from Pseudomonas fluorescens. Northeast Structural Genomics target PlR293L | 分子名称: | Peptidase M16 inactive domain family protein | 著者 | Seetharaman, J, Chen, Y, Fang, F, Xiao, R, Everett, J.K, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2009-03-31 | 公開日 | 2009-05-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of peptidase M16 inactive domain from Pseudomonas fluorescens. Northeast Structural Genomics target PlR293L To be Published
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3EVI
| Crystal structure of the thioredoxin-fold domain of human phosducin-like protein 2 | 分子名称: | DI(HYDROXYETHYL)ETHER, Phosducin-like protein 2, SODIUM ION | 著者 | Lou, X, Bao, R, Zhou, C, Chen, Y. | 登録日 | 2008-10-13 | 公開日 | 2009-03-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of the thioredoxin-fold domain of human phosducin-like protein 2 Acta Crystallogr.,Sect.F, 65, 2009
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3ESH
| Crystal structure of a probable metal-dependent hydrolase from Staphylococcus aureus. Northeast Structural Genomics target ZR314 | 分子名称: | Protein similar to metal-dependent hydrolase | 著者 | Seetharaman, J, Chen, Y, Wang, H, Janjua, H, Foote, E.L, Xiao, R, Nair, R, Everett, J.K, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2008-10-06 | 公開日 | 2008-10-28 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of a probable metal-dependent hydrolase from
Staphylococcus aureus. Northeast Structural Genomics target ZR314 To be Published
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3GQQ
| Crystal structure of the human retinal protein 4 (unc-119 homolog A). Northeast Structural Genomics Consortium target HR3066a | 分子名称: | Protein unc-119 homolog A, UNKNOWN LIGAND | 著者 | Vorobiev, S.M, Chen, Y, Seetharaman, J, Shastry, R, Foote, E.L, Ciccosanti, C, Sahdev, S, Xiao, R, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2009-03-24 | 公開日 | 2009-04-07 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.945 Å) | 主引用文献 | Crystal structure of the human retinal protein 4 (unc-119 homolog A). To be Published
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8W9Y
| The cryo-EM structure of human sphingomyelin synthase-related protein | 分子名称: | Sphingomyelin synthase-related protein 1 | 著者 | Hu, K, Zhang, Q, Chen, Y, Yao, D, Zhou, L, Cao, Y. | 登録日 | 2023-09-06 | 公開日 | 2024-02-28 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis. Nat.Struct.Mol.Biol., 31, 2024
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8W9W
| The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide/phosphoethanolamine | 分子名称: | PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER, Sphingomyelin synthase-related protein 1, ~{N}-[(~{Z},2~{S},3~{R})-1,3-bis(oxidanyl)heptadec-4-en-2-yl]dodecanamide | 著者 | Hu, K, Zhang, Q, Chen, Y, Yao, D, Zhou, L, Cao, Y. | 登録日 | 2023-09-06 | 公開日 | 2024-02-28 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | 主引用文献 | Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis. Nat.Struct.Mol.Biol., 31, 2024
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5XP5
| C-Src in complex with ATP-Chf | 分子名称: | MAGNESIUM ION, Proto-oncogene tyrosine-protein kinase Src, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-[(S)-fluoranyl-[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid | 著者 | Duan, Y, Guo, M, Dai, S, Chen, L, Chen, Y. | 登録日 | 2017-06-01 | 公開日 | 2018-02-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases. J. Am. Chem. Soc., 139, 2017
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2LVN
| Structure of the gp78 CUE domain | 分子名称: | E3 ubiquitin-protein ligase AMFR | 著者 | Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R. | 登録日 | 2012-07-09 | 公開日 | 2012-11-21 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains. Structure, 20, 2012
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2LVO
| Structure of the gp78CUE domain bound to monubiquitin | 分子名称: | E3 ubiquitin-protein ligase AMFR, Ubiquitin | 著者 | Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R. | 登録日 | 2012-07-09 | 公開日 | 2012-11-21 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains. Structure, 20, 2012
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2LVP
| gp78CUE domain bound to the distal ubiquitin of K48-linked diubiquitin | 分子名称: | E3 ubiquitin-protein ligase AMFR, Ubiquitin | 著者 | Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R. | 登録日 | 2012-07-09 | 公開日 | 2012-11-21 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains. Structure, 20, 2012
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2LVQ
| gp78CUE domain bound to the proximal ubiquitin of K48-linked diubiquitin | 分子名称: | E3 ubiquitin-protein ligase AMFR, Ubiquitin | 著者 | Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R. | 登録日 | 2012-07-09 | 公開日 | 2012-11-21 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains. Structure, 20, 2012
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6B0V
| Crystal Structure of small molecule ARS-107 covalently bound to K-Ras G12C | 分子名称: | 1-[3-(4-{[(4,5-dichloro-2-hydroxyphenyl)amino]acetyl}piperazin-1-yl)azetidin-1-yl]propan-1-one, CALCIUM ION, GTPase KRas, ... | 著者 | Hansen, R, Peters, U, Babbar, A, Chen, Y, Feng, J, Janes, M.R, Li, L.-S, Ren, P, Liu, Y, Zarrinkar, P.P. | 登録日 | 2017-09-15 | 公開日 | 2018-05-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | The reactivity-driven biochemical mechanism of covalent KRASG12Cinhibitors. Nat. Struct. Mol. Biol., 25, 2018
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2O3I
| X-ray Crystal Structure of Protein CV_3147 from Chromobacterium violaceum. Northeast Structural Genomics Consortium Target CvR68. | 分子名称: | Hypothetical protein | 著者 | Vorobiev, S.M, Chen, Y, Seetharaman, J, Cunningham, K, Ma, L.C, Janjua, H, Xiao, R, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2006-12-01 | 公開日 | 2006-12-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the hypothetical protein Q7NTB2_CHRVO from Chromobacterium violaceum To be Published
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2P0V
| Crystal structure of BT3781 protein from Bacteroides thetaiotaomicron, Northeast Structural Genomics Target BtR58 | 分子名称: | Hypothetical protein BT3781 | 著者 | Forouhar, F, Chen, Y, Seetharaman, J, Janjua, H, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-03-01 | 公開日 | 2007-03-20 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of BT3781 protein from Bacteroides thetaiotaomicron. To be Published
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5X07
| Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site | 分子名称: | DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Hepatocyte nuclear factor 3-beta | 著者 | Li, J, Guo, M, Zhou, Z, Jiang, L, Chen, X, Qu, L, Wu, D, Chen, Z, Chen, L, Chen, Y. | 登録日 | 2017-01-20 | 公開日 | 2017-08-16 | 最終更新日 | 2017-09-27 | 実験手法 | X-RAY DIFFRACTION (2.796 Å) | 主引用文献 | Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site Biochemistry, 56, 2017
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2OA5
| Crystal structure of ORF52 from Murid herpesvirus (MUHV-4) (Murine gammaherpesvirus 68) at 2.1 A resolution. Northeast Structural Genomics Consortium target MHR28B. | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Hypothetical protein BQLF2 | 著者 | Benach, J, Chen, Y, Seetharaman, J, Janjua, H, Xiao, R, Cunningham, K, Ma, L.-C, Ho, C.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2006-12-14 | 公開日 | 2007-01-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and functional studies of the abundant tegument protein ORF52 from murine gammaherpesvirus 68. J.Biol.Chem., 282, 2007
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5YRP
| Crystal structure of the EAL domain of Mycobacterium smegmatis DcpA | 分子名称: | MAGNESIUM ION, Sensory box/response regulator | 著者 | Chen, H.J, li, N, Luo, Y, Jiang, Y.L, Zhou, C.Z, Chen, Y, Li, Q. | 登録日 | 2017-11-09 | 公開日 | 2018-05-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | The GDP-switched GAF domain of DcpA modulates the concerted synthesis/hydrolysis of c-di-GMP inMycobacterium smegmatis. Biochem. J., 475, 2018
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2PX9
| The intrinsic affinity between E2 and the Cys domain of E1 in Ubiquitin-like modifications | 分子名称: | SUMO-activating enzyme subunit 2, SUMO-conjugating enzyme UBC9 | 著者 | Wang, J.H, Hu, W.D, Cai, S, Lee, B, Song, J, Chen, Y. | 登録日 | 2007-05-14 | 公開日 | 2007-07-24 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | The intrinsic affinity between E2 and the Cys domain of E1 in ubiquitin-like modifications. Mol.Cell, 27, 2007
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5XP7
| C-Src in complex with ATP-CHCl | 分子名称: | GLYCEROL, MAGNESIUM ION, Proto-oncogene tyrosine-protein kinase Src, ... | 著者 | Guo, M, Dai, S, Duan, Y, Chen, L, Chen, Y. | 登録日 | 2017-06-01 | 公開日 | 2017-09-06 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.012 Å) | 主引用文献 | Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases. J. Am. Chem. Soc., 139, 2017
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2PIG
| Crystal structure of ydcK from Salmonella cholerae at 2.38 A resolution. Northeast Structural Genomics target SCR6 | 分子名称: | Putative transferase, ZINC ION | 著者 | Benach, J, Chen, Y, Vorobiev, S.M, Seetharaman, J, Ho, C.K, Janjua, H, Conover, K, Ma, L.-C, Xiao, R, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-04-13 | 公開日 | 2007-04-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Crystal structure of ydcK from Salmonella cholerae at 2.38 A resolution. To be Published
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6B0Y
| Crystal Structure of small molecule ARS-917 covalently bound to K-Ras G12C | 分子名称: | 1-{4-[6-chloro-7-(2-fluorophenyl)quinazolin-4-yl]piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ... | 著者 | Hansen, R, Peters, U, Babbar, A, Chen, Y, Feng, J, Janes, M.R, Li, L.-S, Ren, P, Liu, Y, Zarrinkar, P.P. | 登録日 | 2017-09-15 | 公開日 | 2018-05-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | The reactivity-driven biochemical mechanism of covalent KRASG12Cinhibitors. Nat. Struct. Mol. Biol., 25, 2018
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2P0Y
| Crystal structure of Q88YI3_LACPL from Lactobacillus plantarum. Northeast Structural Genomics Consortium target LpR6 | 分子名称: | Hypothetical protein lp_0780 | 著者 | Benach, J, Chen, Y, Seetharaman, J, Chi, K.H, Janjua, H, Cunningham, K, Ma, L.C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-03-01 | 公開日 | 2007-03-27 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of Q88YI3_LACPL from Lactobacillus plantarum. To be Published
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2QYK
| Crystal structure of PDE4A10 in complex with inhibitor NPV | 分子名称: | 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, Cyclic AMP-specific phosphodiesterase HSPDE4A10, MAGNESIUM ION, ... | 著者 | Wang, H, Peng, M, Chen, Y, Geng, J, Robinson, H, Houslay, M. | 登録日 | 2007-08-15 | 公開日 | 2008-04-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem.J., 408, 2007
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3LD7
| Crystal structure of the Lin0431 protein from Listeria innocua, Northeast Structural Genomics Consortium Target LkR112 | 分子名称: | Lin0431 protein | 著者 | Vorobiev, S, Chen, Y, Lee, D, Patel, D.J, Ciccosanti, C, Sahdev, S, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-01-12 | 公開日 | 2010-01-26 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (1.547 Å) | 主引用文献 | Crystal structure of the Lin0431 protein from Listeria innocua To be Published
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3LD0
| Crystal structure of B.licheniformis Anti-TRAP protein, an antagonist of TRAP-RNA interactions | 分子名称: | Inhibitor of TRAP, regulated by T-BOX (Trp) sequence RtpA, MAGNESIUM ION, ... | 著者 | Shevtsov, M.B, Chen, Y, Isupov, M.N, Gollnick, P, Antson, A.A. | 登録日 | 2010-01-12 | 公開日 | 2010-02-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Bacillus licheniformis Anti-TRAP can assemble into two types of dodecameric particles with the same symmetry but inverted orientation of trimers. J.Struct.Biol., 170, 2010
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