8W9W

The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide/phosphoethanolamine

Summary for 8W9W

• Entry DOI: 10.2210/pdb8w9w/pdb
• EMDB information: 37383
• Descriptor: Sphingomyelin synthase-related protein 1, ~{N}-[(~{Z},2~{S},3~{R})-1,3-bis(oxidanyl)heptadec-4-en-2-yl]dodecanamide, PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER (3 entities in total)
• Functional Keywords: synthase, sphingomyelin, cpe, membrane protein, lipid metabolism
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 189710.03

Authors

Hu, K.,Zhang, Q.,Chen, Y.,Yao, D.,Zhou, L.,Cao, Y. (deposition date: 2023-09-06, release date: 2024-02-28, Last modification date: 2024-07-03)

• Primary citation: Hu, K.,Zhang, Q.,Chen, Y.,Yang, J.,Xia, Y.,Rao, B.,Li, S.,Shen, Y.,Cao, M.,Lu, H.,Qin, A.,Jiang, X.C.,Yao, D.,Zhao, J.,Zhou, L.,Cao, Y.; Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.; Nat.Struct.Mol.Biol., 31:884-895, 2024; PubMed: 38388831; DOI: 10.1038/s41594-024-01237-2

Experimental method

ELECTRON MICROSCOPY (3.74 Å)