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4PU6
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BU of 4pu6 by Molmil
Crystal structure of potassium-dependent plant-type L-asparaginase from Phaseolus vulgaris in complex with K+ cations
分子名称: ASPARTIC ACID, L-ASPARAGINASE ALPHA SUBUNIT, L-ASPARAGINASE BETA SUBUNIT, ...
著者Bejger, M, Gilski, M, Imiolczyk, B, Jaskolski, M.
登録日2014-03-12
公開日2014-09-03
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Na+/K+ exchange switches the catalytic apparatus of potassium-dependent plant L-asparaginase
Acta Crystallogr.,Sect.D, 70, 2014
3HP1
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BU of 3hp1 by Molmil
Crystal structure of human dCK R104M/D133A in complex with L-dT and ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase, L-deoxythymidine
著者Hazra, S, Lavie, A.
登録日2009-06-03
公開日2009-06-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Extending Thymidine Kinase Activity to the Catalytic Repertoire of Human Deoxycytidine Kinase.
Biochemistry, 48, 2009
2TMK
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BU of 2tmk by Molmil
YEAST THYMIDYLATE KINASE COMPLEXED WITH 3'-AZIDO-3'-DEOXYTHYMIDINE MONOPHOSPHATE (AZT-MP)
分子名称: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, SULFATE ION, THYMIDYLATE KINASE
著者Lavie, A, Schlichting, I.
登録日1997-06-12
公開日1998-06-17
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.
Nat.Struct.Biol., 4, 1997
3KFX
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BU of 3kfx by Molmil
Human dCK complex with 5-Me dC and ADP
分子名称: 5-METHYL-2'-DEOXYCYTIDINE, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase
著者Hazra, S, Lavie, A.
登録日2009-10-28
公開日2010-09-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues .
Biochemistry, 49, 2010
3MJR
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BU of 3mjr by Molmil
Human dCK complex with Acyclic Nucleoside
分子名称: 9-HYROXYETHOXYMETHYLGUANINE, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Hazra, S, Lavie, A.
登録日2010-04-13
公開日2010-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Sugar Ring of the Nucleoside Is Required for Productive Substrate Positioning in the Active Site of Human Deoxycytidine Kinase (dCK): Implications for the Development of dCK-Activated Acyclic Guanine Analogues.
J.Med.Chem., 53, 2010
1NCL
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BU of 1ncl by Molmil
THERMAL STABILITY OF HEXAMERIC AND TETRAMERIC NUCLEOSIDE, DIPHOSPHATE KINASES
分子名称: NUCLEOSIDE DIPHOSPHATE KINASE
著者Janin, J, Morera, S, Lascu, I.
登録日1996-03-22
公開日1996-11-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Thermal stability of hexameric and tetrameric nucleoside diphosphate kinases. Effect of subunit interaction.
J.Biol.Chem., 271, 1996
2CKO
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BU of 2cko by Molmil
Crystal structure of Human Choline Kinase alpha 2
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHOLINE KINASE ALPHA
著者Malito, E, Lavie, A.
登録日2006-04-20
公開日2006-10-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Elucidation of Human Choline Kinase Crystal Structures in Complex with the Products Adp or Phosphocholine.
J.Mol.Biol., 364, 2006
2CKP
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BU of 2ckp by Molmil
Crystal structure of Human Choline Kinase alpha-2 in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHOLINE KINASE ALPHA
著者Malito, E, Lavie, A.
登録日2006-04-20
公開日2006-10-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Elucidation of Human Choline Kinase Crystal Structures in Complex with the Products Adp or Phosphocholine.
J.Mol.Biol., 364, 2006
2CKQ
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BU of 2ckq by Molmil
Crystal structure of Human Choline Kinase alpha 2 in complex with Phosphocholine
分子名称: CHOLINE KINASE ALPHA, PHOSPHOCHOLINE
著者Malito, E, Lavie, A.
登録日2006-04-20
公開日2006-10-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Elucidation of Human Choline Kinase Crystal Structures in Complex with the Products Adp or Phosphocholine.
J.Mol.Biol., 364, 2006
3QEN
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BU of 3qen by Molmil
S74E dCK in complex with 5-bromodeoxycytidine and UDP
分子名称: 5-bromo-2'-deoxycytidine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Lavie, A, Hazra, S.
登録日2011-01-20
公開日2011-03-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.997 Å)
主引用文献Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
3QEO
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BU of 3qeo by Molmil
S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP
分子名称: Deoxycytidine kinase, L-deoxythymidine, URIDINE-5'-DIPHOSPHATE
著者Lavie, A, Hazra, S.
登録日2011-01-20
公開日2011-03-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.897 Å)
主引用文献Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
3QEJ
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BU of 3qej by Molmil
S74E-dCK mutant in complex with UDP
分子名称: Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Hazra, S, Lavie, A.
登録日2011-01-20
公開日2011-03-16
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
2ZIA
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BU of 2zia by Molmil
C4S dCK variant of dCK in complex with cladribine+UDP
分子名称: 2-chloro-2'-deoxyadenosine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Sabini, E, Lavie, A.
登録日2008-02-13
公開日2008-07-08
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase
J.Med.Chem., 51, 2008
2ZI5
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BU of 2zi5 by Molmil
C4S dCK variant of dCK in complex with L-dA+UDP
分子名称: (2S,3R,5S)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Sabini, E, Lavie, A.
登録日2008-02-13
公開日2008-04-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structural basis for substrate promiscuity of dCK
J.Mol.Biol., 378, 2008
2ZI9
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BU of 2zi9 by Molmil
C4S-E247A dCK variant of dCK in complex with cladribine+ADP
分子名称: 2-chloro-2'-deoxyadenosine, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase
著者Sabini, E, Lavie, A.
登録日2008-02-13
公開日2008-07-08
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase
J.Med.Chem., 51, 2008
2ZI7
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BU of 2zi7 by Molmil
C4S dCK variant of dCK in complex with D-dG+UDP
分子名称: 2'-DEOXY-GUANOSINE, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Sabini, E, Lavie, A.
登録日2008-02-13
公開日2008-07-08
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase
J.Med.Chem., 51, 2008
2ZI3
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BU of 2zi3 by Molmil
C4S-E247A dCK variant of dCK in complex with D-dA+ADP
分子名称: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase
著者Sabini, E, Lavie, A.
登録日2008-02-13
公開日2008-04-22
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for substrate promiscuity of dCK
J.Mol.Biol., 378, 2008
2ZI4
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BU of 2zi4 by Molmil
C4S dCK variant of dCK in complex with L-dA+ADP
分子名称: (2S,3R,5S)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase, ...
著者Sabini, E, Lavie, A.
登録日2008-02-13
公開日2008-04-22
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for substrate promiscuity of dCK
J.Mol.Biol., 378, 2008
2ZI6
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BU of 2zi6 by Molmil
C4S dCK variant of dCK in complex with D-dA+UDP
分子名称: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Sabini, E, Lavie, A.
登録日2008-02-13
公開日2008-04-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structural basis for substrate promiscuity of dCK
J.Mol.Biol., 378, 2008
2QJF
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BU of 2qjf by Molmil
Crystal structure of ATP-sulfurylase domain of human PAPS synthetase 1
分子名称: ADENOSINE-5'-PHOSPHOSULFATE, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1, POTASSIUM ION
著者Sekulic, N, Lavie, A.
登録日2007-07-07
公開日2008-11-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献ATP-sulfurylase domain of human bifunctional PAPS-synthetase oscillates between dimeric and monomeric forms
To be Published
4OSY
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BU of 4osy by Molmil
STRUCTURE of FULLY-CLEAVED GLYCINE-BOUND HUMAN L-ASPARAGINASE PROTEIN
分子名称: GLYCINE, Isoaspartyl peptidase/L-asparaginase, SODIUM ION
著者Nomme, J, Lavie, A.
登録日2014-02-13
公開日2014-03-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Free glycine accelerates the autoproteolytic activation of human asparaginase.
Chem.Biol., 20, 2013
4PVQ
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BU of 4pvq by Molmil
Crystal structure of sulfate-bound human l-asparaginase protein
分子名称: IODIDE ION, Isoaspartyl peptidase/L-asparaginase, SODIUM ION, ...
著者Nomme, J, Lavie, A.
登録日2014-03-18
公開日2014-03-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis.
Biochemistry, 51, 2012
4OSX
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BU of 4osx by Molmil
STRUCTURE of UNCLEAVED GLYCINE-BOUND HUMAN L-ASPARAGINASE PROTEIN
分子名称: GLYCINE, Isoaspartyl peptidase/L-asparaginase, SODIUM ION
著者Nomme, J, Lavie, A.
登録日2014-02-13
公開日2014-03-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Free Glycine Accelerates the Autoproteolytic Activation of Human Asparaginase.
Chem.Biol., 20, 2013
2NO9
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BU of 2no9 by Molmil
The structure of deoxycytidine kinase complexed with troxacitabine and ADP.
分子名称: 4-AMINO-1-[(2S,4S)-2-(HYDROXYMETHYL)-1,3-DIOXOLAN-4-YL]PYRIMIDIN-2(1H)-ONE, ADENOSINE-5'-DIPHOSPHATE, deoxycytidine kinase
著者Sabini, E, Lavie, A.
登録日2006-10-25
公開日2007-02-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase.
Nucleic Acids Res., 35, 2007
2PEZ
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BU of 2pez by Molmil
Crystal structrue of deletion mutant of APS-kinase domain of human PAPS-synthetase 1 in complex with cyclic PAPS and dADP
分子名称: (2S,3AR,4R,6R,6AR)-4-(6-AMINO-9H-PURIN-9-YL)-6-({[(R)-HYDROXY(SULFOOXY)PHOSPHORYL]OXY}METHYL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-2-OL 2-OXIDE, 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1)
著者Sekulic, N, Lavie, A.
登録日2007-04-03
公開日2007-05-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural mechanism for substrate inhibition of the adenosine 5'-phosphosulfate kinase domain of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 and its ramifications for enzyme regulation.
J.Biol.Chem., 282, 2007

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