2ZIA
C4S dCK variant of dCK in complex with cladribine+UDP
Summary for 2ZIA
| Entry DOI | 10.2210/pdb2zia/pdb |
| Related | 1P60 2NO1 2NO7 2ZI3 2ZI4 2ZI5 2ZI6 2ZI7 2ZI9 |
| Descriptor | Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE, 2-chloro-2'-deoxyadenosine, ... (4 entities in total) |
| Functional Keywords | dck, purine, deoxycytidine kinase, nucleoside, cladribine, 2-chloro-2'-deoxyadenosine, deoxyadenosine analog, udp, atp-binding, nucleotide-binding, nucleus, phosphoprotein, transferase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus: P27707 |
| Total number of polymer chains | 2 |
| Total formula weight | 66524.72 |
| Authors | Sabini, E.,Lavie, A. (deposition date: 2008-02-13, release date: 2008-07-08, Last modification date: 2023-11-01) |
| Primary citation | Sabini, E.,Hazra, S.,Konrad, M.,Lavie, A. Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase J.Med.Chem., 51:4219-4225, 2008 Cited by PubMed: 18570408DOI: 10.1021/jm800134t PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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