2ZIA

C4S dCK variant of dCK in complex with cladribine+UDP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Deoxycytidine kinase	polymer	279	32572.5	2	UniProt (P27707) Pfam (PF01712) In PDB	Homo sapiens (Human)	dCK
2	A, B	URIDINE-5'-DIPHOSPHATE	non-polymer		404.2	2	Chemie (UDP)
3	A, B	2-chloro-2'-deoxyadenosine	non-polymer		285.7	2	Chemie (CL9)
4		water	water		18.0	278	Chemie (HOH)

Sequence modifications

A, B: 1 - 260 (UniProt: P27707)

PDB	External Database	Details
Met -18	-	expression tag
Gly -17	-	expression tag
Ser -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Ser 9	Cys 9	engineered mutation
Ser 45	Cys 45	engineered mutation
Ser 59	Cys 59	engineered mutation
Ser 146	Cys 146	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65145.0
Non-Polymers*	Number of molecules	4
	Total formula weight	1379.7
All*	Total formula weight	66524.7

*Water molecules are not included.