3QEJ

S74E-dCK mutant in complex with UDP

Summary for 3QEJ

DescriptorDeoxycytidine kinase, URIDINE-5'-DIPHOSPHATE (3 entities in total)
Functional Keywordsalpha/beta, phosphoryl transfer, atp binding, phosphorylation, transferase
Biological sourceHomo sapiens (human)
Cellular locationNucleus P27707
Total number of polymer chains2
Total molecular weight66037.42
Authors
Hazra, S.,Lavie, A. (deposition date: 2011-01-20, release date: 2011-03-16, Last modification date: 2011-07-13)
Primary citation
Hazra, S.,Szewczak, A.,Ort, S.,Konrad, M.,Lavie, A.
Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50:2870-2880, 2011
PubMed: 21351740 (PDB entries with the same primary citation)
DOI: 10.1021/bi2001032
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.49 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.197160.7%8.7%1.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report