7PGU
 
 | | Autoinhibited structure of human neurofibromin isoform 2 stabilized by Zinc. | | 分子名称: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, Neurofibromin, ZINC ION | | 著者 | Naschberger, A, Baradaran, R, Carroni, M, Rupp, B. | | 登録日 | 2021-08-15 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | The structure of neurofibromin isoform 2 reveals different functional states.
Nature, 599, 2021
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7PGT
 | | The structure of human neurofibromin isoform 2 in opened conformation. | | 分子名称: | Neurofibromin, ZINC ION | | 著者 | Naschberger, A, Baradaran, R, Carroni, M, Rupp, B. | | 登録日 | 2021-08-15 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | The structure of neurofibromin isoform 2 reveals different functional states.
Nature, 599, 2021
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7PGS
 | | Consensus structure of human Neurofibromin isoform 2 | | 分子名称: | Neurofibromin, ZINC ION | | 著者 | Naschberger, A, Baradaran, R, Carroni, M, Rupp, B. | | 登録日 | 2021-08-15 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | The structure of neurofibromin isoform 2 reveals different functional states.
Nature, 599, 2021
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7PGR
 | | The structure of human neurofibromin isoform 2 in closed conformation | | 分子名称: | Neurofibromin, ZINC ION | | 著者 | Naschberger, A, Baradaran, R, Carroni, M, Rupp, B. | | 登録日 | 2021-08-15 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | The structure of neurofibromin isoform 2 reveals different functional states.
Nature, 599, 2021
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7PGP
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7PGQ
 | | GAP-SecPH region of human neurofibromin isoform 2 in closed conformation. | | 分子名称: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, Neurofibromin, ZINC ION | | 著者 | Naschberger, A, Baradaran, R, Carroni, M, Rupp, B. | | 登録日 | 2021-08-15 | | 公開日 | 2022-10-26 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | The structure of neurofibromin isoform 2 reveals different functional states.
Nature, 599, 2021
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8PPV
 | | Intermediate conformer of Pyrococcus abyssi DNA polymerase D (PolD) bound to a primer/template substrate containing three consecutive mismatches | | 分子名称: | DNA (5'-D(*P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(G7P)P*(PST)P*(PST)P*(PST))-3'), DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA polymerase II small subunit, ... | | 著者 | Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. | | 登録日 | 2023-07-10 | | 公開日 | 2023-12-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases.
Nat Commun, 14, 2023
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8PPU
 | | Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing three consecutive mismatches | | 分子名称: | DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(C7R)P*(PST)P*(PST)P*(PST))-3'), DNA polymerase II small subunit, ... | | 著者 | Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. | | 登録日 | 2023-07-10 | | 公開日 | 2023-12-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases.
Nat Commun, 14, 2023
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8PPT
 | | Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing a mismatch | | 分子名称: | DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*GP*CP*TP*TP*T)-3'), DNA polymerase II small subunit, ... | | 著者 | Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. | | 登録日 | 2023-07-10 | | 公開日 | 2023-12-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases.
Nat Commun, 14, 2023
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6XZ6
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6ZGK
 | | GLIC pentameric ligand-gated ion channel, pH 3 | | 分子名称: | Proton-gated ion channel | | 著者 | Rovsnik, U, Zhuang, Y, Forsberg, B.O, Carroni, M, Yvonnesdotter, L, Howard, R.J, Lindahl, E. | | 登録日 | 2020-06-18 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations.
Life Sci Alliance, 4, 2021
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6ZGD
 | | GLIC pentameric ligand-gated ion channel, pH 7 | | 分子名称: | Proton-gated ion channel | | 著者 | Rovsnik, U, Zhuang, Y, Forsberg, B.O, Carroni, M, Yvonnesdotter, L, Howard, R.J, Lindahl, E. | | 登録日 | 2020-06-18 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations.
Life Sci Alliance, 4, 2021
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6ZGJ
 | | GLIC pentameric ligand-gated ion channel, pH 5 | | 分子名称: | Proton-gated ion channel | | 著者 | Rovsnik, U, Zhuang, Y, Forsberg, B.O, Carroni, M, Yvonnesdotter, L, Howard, R.J, Lindahl, E. | | 登録日 | 2020-06-18 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations.
Life Sci Alliance, 4, 2021
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6SOY
 | | Trypanosoma brucei transferrin receptor in complex with human transferrin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ESAG6, subunit of heterodimeric transferrin receptor, ... | | 著者 | Trevor, C, Carrington, M, Higgins, M.K. | | 登録日 | 2019-08-30 | | 公開日 | 2019-11-06 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion.
Nat Microbiol, 4, 2019
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6SOZ
 | | Glycosylated Trypanosoma brucei transferrin receptor in complex with human transferrin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ESAG6, ... | | 著者 | Trevor, C, Carrington, M, Higgins, M.K. | | 登録日 | 2019-08-30 | | 公開日 | 2019-11-06 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | | 主引用文献 | Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion.
Nat Microbiol, 4, 2019
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6FU8
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6FB3
 | | Teneurin 2 Partial Extracellular Domain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Teneurin-2, ... | | 著者 | Jackson, V.A, Carrasquero, M, Lowe, E.D, Seiradake, E. | | 登録日 | 2017-12-18 | | 公開日 | 2018-03-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction.
Nat Commun, 9, 2018
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1XU6
 | | Structure of the C-terminal domain from Trypanosoma brucei Variant Surface Glycoprotein MITat1.2 | | 分子名称: | Variant surface glycoprotein MITAT 1.2 | | 著者 | Chattopadhyay, A, Jones, N.G, Nietlispach, D, Nielsen, P.R, Voorheis, H.P, Mott, H.R, Carrington, M. | | 登録日 | 2004-10-25 | | 公開日 | 2004-11-30 | | 最終更新日 | 2011-07-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2
J.Biol.Chem., 280, 2004
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3TTI
 | | Crystal Structure of JNK3 complexed with CC-930, an orally active anti-fibrotic JNK inhibitor | | 分子名称: | GLYCEROL, Mitogen-activated protein kinase 10, trans-4-({9-[(3S)-tetrahydrofuran-3-yl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl}amino)cyclohexanol | | 著者 | Plantevin-Krenitsky, V, Nadolny, L, Delgado, M, Ayala, L, Clareen, S, Hilgraf, R, Albers, R, Hegde, S, D'Sidocky, N, Sapienza, J, Wright, J, McCarrick, M, Bahmanyar, S, Chamberlain, P, Delker, S.L, Muir, J, Giegel, D, Xu, L, Celeridad, M, Lachowitzer, J, Bennett, B, Moghaddam, M, Khatsenko, O, Katz, J, Fan, R, Bai, A, Tang, Y, Shirley, M.A, Benish, B, Bodine, T, Blease, K, Raymon, H, Cathers, B.E, Satoh, Y. | | 登録日 | 2011-09-14 | | 公開日 | 2012-02-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.
Bioorg.Med.Chem.Lett., 22, 2012
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2JWH
 | | Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein | | 分子名称: | Variant surface glycoprotein ILTAT 1.24 | | 著者 | Jones, N.G, Nietlispach, D, Sharma, R, Burke, D.F, Eyres, I, Mues, M, Mott, H.R, Carrington, M. | | 登録日 | 2007-10-12 | | 公開日 | 2007-11-13 | | 最終更新日 | 2011-07-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein
J.Biol.Chem., 283, 2008
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2JWG
 | | Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein | | 分子名称: | Variant surface glycoprotein ILTAT 1.24 | | 著者 | Jones, N.G, Nietlispach, D, Sharma, R, Burke, D.F, Eyres, I, Mues, M, Mott, H.R, Carrington, M. | | 登録日 | 2007-10-12 | | 公開日 | 2007-11-13 | | 最終更新日 | 2011-07-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein
J.Biol.Chem., 283, 2008
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3OLS
 | | Crystal structure of estrogen receptor beta ligand binding domain | | 分子名称: | ESTRADIOL, Estrogen receptor beta, Nuclear receptor coactivator 1 | | 著者 | Moecklinghoff, S, Rose, R, Carraz, M, Visser, A, Ottmann, C, Brunsveld, L. | | 登録日 | 2010-08-26 | | 公開日 | 2010-11-17 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Synthesis and crystal structure of a phosphorylated estrogen receptor ligand binding domain.
Chembiochem, 11, 2010
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5OFO
 | | Cryo EM structure of the E. coli disaggregase ClpB (BAP form, DWB mutant), in the ATPgammaS state, bound to the model substrate casein | | 分子名称: | Chaperone protein ClpB,ATP-dependent Clp protease ATP-binding subunit ClpA,Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | 著者 | Deville, C, Carroni, M, Franke, K.B, Topf, M, Bukau, B, Mogk, A, Saibil, H.R. | | 登録日 | 2017-07-11 | | 公開日 | 2017-08-16 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.
Sci Adv, 3, 2017
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5AFB
 | | Crystal structure of the Latrophilin3 Lectin and Olfactomedin Domains | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | | 著者 | Jackson, V.A, del Toro, D, Carrasquero, M, Roversi, P, Harlos, K, Klein, R, Seiradake, E. | | 登録日 | 2015-01-21 | | 公開日 | 2015-03-18 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Structural Basis of Latrophilin-Flrt Interaction.
Structure, 23, 2015
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5OG1
 | | Cryo EM structure of the E. coli disaggregase ClpB (BAP form, DWB mutant), in the ATPgammaS state | | 分子名称: | Chaperone protein ClpB,ATP-dependent Clp protease ATP-binding subunit ClpA,Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | 著者 | Deville, C, Carroni, M, Franke, K.B, Topf, M, Bukau, B, Mogk, A, Saibil, H.R. | | 登録日 | 2017-07-11 | | 公開日 | 2017-08-16 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.
Sci Adv, 3, 2017
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