7PGQ

GAP-SecPH region of human neurofibromin isoform 2 in closed conformation.

Summary for 7PGQ

Entry DOI	10.2210/pdb7pgq/pdb
EMDB information	13392
Descriptor	Neurofibromin, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ZINC ION (3 entities in total)
Functional Keywords	neurofibromin, cancer, gap, ras, neurofibromatosis type 1, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	640300.73
Authors	Naschberger, A.,Baradaran, R.,Carroni, M.,Rupp, B. (deposition date: 2021-08-15, release date: 2022-10-26)
Primary citation	Naschberger, A.,Baradaran, R.,Rupp, B.,Carroni, M. The structure of neurofibromin isoform 2 reveals different functional states. Nature, 599:315-319, 2021 Cited by PubMed: 34707296 DOI: 10.1038/s41586-021-04024-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation