7PGQ

GAP-SecPH region of human neurofibromin isoform 2 in closed conformation.

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0000165	biological_process	MAPK cascade
F	0001525	biological_process	angiogenesis
F	0001649	biological_process	osteoblast differentiation
F	0001656	biological_process	metanephros development
F	0001666	biological_process	response to hypoxia
F	0001889	biological_process	liver development
F	0001935	biological_process	endothelial cell proliferation
F	0001937	biological_process	negative regulation of endothelial cell proliferation
F	0001938	biological_process	positive regulation of endothelial cell proliferation
F	0001952	biological_process	regulation of cell-matrix adhesion
F	0001953	biological_process	negative regulation of cell-matrix adhesion
F	0002686	biological_process	negative regulation of leukocyte migration
F	0005096	molecular_function	GTPase activator activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006469	biological_process	negative regulation of protein kinase activity
F	0006606	biological_process	protein import into nucleus
F	0006915	biological_process	apoptotic process
F	0007154	biological_process	cell communication
F	0007265	biological_process	Ras protein signal transduction
F	0007269	biological_process	neurotransmitter secretion
F	0007405	biological_process	neuroblast proliferation
F	0007406	biological_process	negative regulation of neuroblast proliferation
F	0007420	biological_process	brain development
F	0007422	biological_process	peripheral nervous system development
F	0007507	biological_process	heart development
F	0007519	biological_process	skeletal muscle tissue development
F	0008283	biological_process	cell population proliferation
F	0008285	biological_process	negative regulation of cell population proliferation
F	0008289	molecular_function	lipid binding
F	0008429	molecular_function	phosphatidylethanolamine binding
F	0008542	biological_process	visual learning
F	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
F	0010468	biological_process	regulation of gene expression
F	0010626	biological_process	negative regulation of Schwann cell proliferation
F	0014009	biological_process	glial cell proliferation
F	0014010	biological_process	Schwann cell proliferation
F	0014044	biological_process	Schwann cell development
F	0016020	cellular_component	membrane
F	0016477	biological_process	cell migration
F	0016525	biological_process	negative regulation of angiogenesis
F	0016601	biological_process	Rac protein signal transduction
F	0021510	biological_process	spinal cord development
F	0021764	biological_process	amygdala development
F	0021897	biological_process	forebrain astrocyte development
F	0021915	biological_process	neural tube development
F	0021987	biological_process	cerebral cortex development
F	0022011	biological_process	myelination in peripheral nervous system
F	0030036	biological_process	actin cytoskeleton organization
F	0030198	biological_process	extracellular matrix organization
F	0030199	biological_process	collagen fibril organization
F	0030316	biological_process	osteoclast differentiation
F	0030325	biological_process	adrenal gland development
F	0030336	biological_process	negative regulation of cell migration
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0031210	molecular_function	phosphatidylcholine binding
F	0032228	biological_process	regulation of synaptic transmission, GABAergic
F	0033024	biological_process	mast cell apoptotic process
F	0033027	biological_process	positive regulation of mast cell apoptotic process
F	0033028	biological_process	myeloid cell apoptotic process
F	0033034	biological_process	positive regulation of myeloid cell apoptotic process
F	0034605	biological_process	cellular response to heat
F	0035021	biological_process	negative regulation of Rac protein signal transduction
F	0036135	biological_process	Schwann cell migration
F	0042060	biological_process	wound healing
F	0042127	biological_process	regulation of cell population proliferation
F	0042308	biological_process	negative regulation of protein import into nucleus
F	0043065	biological_process	positive regulation of apoptotic process
F	0043087	biological_process	regulation of GTPase activity
F	0043407	biological_process	negative regulation of MAP kinase activity
F	0043408	biological_process	regulation of MAPK cascade
F	0043409	biological_process	negative regulation of MAPK cascade
F	0043473	biological_process	pigmentation
F	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
F	0043525	biological_process	positive regulation of neuron apoptotic process
F	0043535	biological_process	regulation of blood vessel endothelial cell migration
F	0043547	biological_process	positive regulation of GTPase activity
F	0045124	biological_process	regulation of bone resorption
F	0045671	biological_process	negative regulation of osteoclast differentiation
F	0045685	biological_process	regulation of glial cell differentiation
F	0045762	biological_process	positive regulation of adenylate cyclase activity
F	0045765	biological_process	regulation of angiogenesis
F	0046580	biological_process	negative regulation of Ras protein signal transduction
F	0046929	biological_process	negative regulation of neurotransmitter secretion
F	0048144	biological_process	fibroblast proliferation
F	0048147	biological_process	negative regulation of fibroblast proliferation
F	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
F	0048485	biological_process	sympathetic nervous system development
F	0048593	biological_process	camera-type eye morphogenesis
F	0048708	biological_process	astrocyte differentiation
F	0048709	biological_process	oligodendrocyte differentiation
F	0048712	biological_process	negative regulation of astrocyte differentiation
F	0048715	biological_process	negative regulation of oligodendrocyte differentiation
F	0048745	biological_process	smooth muscle tissue development
F	0048820	biological_process	hair follicle maturation
F	0048844	biological_process	artery morphogenesis
F	0048853	biological_process	forebrain morphogenesis
F	0050890	biological_process	cognition
F	0051402	biological_process	neuron apoptotic process
F	0060253	biological_process	negative regulation of glial cell proliferation
F	0060291	biological_process	long-term synaptic potentiation
F	0061534	biological_process	gamma-aminobutyric acid secretion, neurotransmission
F	0061535	biological_process	glutamate secretion, neurotransmission
F	0070372	biological_process	regulation of ERK1 and ERK2 cascade
F	0070662	biological_process	mast cell proliferation
F	0070667	biological_process	negative regulation of mast cell proliferation
F	0071887	biological_process	leukocyte apoptotic process
F	0072089	biological_process	stem cell proliferation
F	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
F	0097529	biological_process	myeloid leukocyte migration
F	0098597	biological_process	observational learning
F	0098793	cellular_component	presynapse
F	0098978	cellular_component	glutamatergic synapse
F	0099175	biological_process	regulation of postsynapse organization
F	1900148	biological_process	negative regulation of Schwann cell migration
F	1900271	biological_process	regulation of long-term synaptic potentiation
F	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
F	1904738	biological_process	vascular associated smooth muscle cell migration
F	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
F	1990874	biological_process	vascular associated smooth muscle cell proliferation
F	2000108	biological_process	positive regulation of leukocyte apoptotic process
F	2000647	biological_process	negative regulation of stem cell proliferation
F	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
N	0000165	biological_process	MAPK cascade
N	0001525	biological_process	angiogenesis
N	0001649	biological_process	osteoblast differentiation
N	0001656	biological_process	metanephros development
N	0001666	biological_process	response to hypoxia
N	0001889	biological_process	liver development
N	0001935	biological_process	endothelial cell proliferation
N	0001937	biological_process	negative regulation of endothelial cell proliferation
N	0001938	biological_process	positive regulation of endothelial cell proliferation
N	0001952	biological_process	regulation of cell-matrix adhesion
N	0001953	biological_process	negative regulation of cell-matrix adhesion
N	0002686	biological_process	negative regulation of leukocyte migration
N	0005096	molecular_function	GTPase activator activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005730	cellular_component	nucleolus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006469	biological_process	negative regulation of protein kinase activity
N	0006606	biological_process	protein import into nucleus
N	0006915	biological_process	apoptotic process
N	0007154	biological_process	cell communication
N	0007265	biological_process	Ras protein signal transduction
N	0007269	biological_process	neurotransmitter secretion
N	0007405	biological_process	neuroblast proliferation
N	0007406	biological_process	negative regulation of neuroblast proliferation
N	0007420	biological_process	brain development
N	0007422	biological_process	peripheral nervous system development
N	0007507	biological_process	heart development
N	0007519	biological_process	skeletal muscle tissue development
N	0008283	biological_process	cell population proliferation
N	0008285	biological_process	negative regulation of cell population proliferation
N	0008289	molecular_function	lipid binding
N	0008429	molecular_function	phosphatidylethanolamine binding
N	0008542	biological_process	visual learning
N	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
N	0010468	biological_process	regulation of gene expression
N	0010626	biological_process	negative regulation of Schwann cell proliferation
N	0014009	biological_process	glial cell proliferation
N	0014010	biological_process	Schwann cell proliferation
N	0014044	biological_process	Schwann cell development
N	0016020	cellular_component	membrane
N	0016477	biological_process	cell migration
N	0016525	biological_process	negative regulation of angiogenesis
N	0016601	biological_process	Rac protein signal transduction
N	0021510	biological_process	spinal cord development
N	0021764	biological_process	amygdala development
N	0021897	biological_process	forebrain astrocyte development
N	0021915	biological_process	neural tube development
N	0021987	biological_process	cerebral cortex development
N	0022011	biological_process	myelination in peripheral nervous system
N	0030036	biological_process	actin cytoskeleton organization
N	0030198	biological_process	extracellular matrix organization
N	0030199	biological_process	collagen fibril organization
N	0030316	biological_process	osteoclast differentiation
N	0030325	biological_process	adrenal gland development
N	0030336	biological_process	negative regulation of cell migration
N	0030424	cellular_component	axon
N	0030425	cellular_component	dendrite
N	0031210	molecular_function	phosphatidylcholine binding
N	0032228	biological_process	regulation of synaptic transmission, GABAergic
N	0033024	biological_process	mast cell apoptotic process
N	0033027	biological_process	positive regulation of mast cell apoptotic process
N	0033028	biological_process	myeloid cell apoptotic process
N	0033034	biological_process	positive regulation of myeloid cell apoptotic process
N	0034605	biological_process	cellular response to heat
N	0035021	biological_process	negative regulation of Rac protein signal transduction
N	0036135	biological_process	Schwann cell migration
N	0042060	biological_process	wound healing
N	0042127	biological_process	regulation of cell population proliferation
N	0042308	biological_process	negative regulation of protein import into nucleus
N	0043065	biological_process	positive regulation of apoptotic process
N	0043087	biological_process	regulation of GTPase activity
N	0043407	biological_process	negative regulation of MAP kinase activity
N	0043408	biological_process	regulation of MAPK cascade
N	0043409	biological_process	negative regulation of MAPK cascade
N	0043473	biological_process	pigmentation
N	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
N	0043525	biological_process	positive regulation of neuron apoptotic process
N	0043535	biological_process	regulation of blood vessel endothelial cell migration
N	0043547	biological_process	positive regulation of GTPase activity
N	0045124	biological_process	regulation of bone resorption
N	0045671	biological_process	negative regulation of osteoclast differentiation
N	0045685	biological_process	regulation of glial cell differentiation
N	0045762	biological_process	positive regulation of adenylate cyclase activity
N	0045765	biological_process	regulation of angiogenesis
N	0046580	biological_process	negative regulation of Ras protein signal transduction
N	0046929	biological_process	negative regulation of neurotransmitter secretion
N	0048144	biological_process	fibroblast proliferation
N	0048147	biological_process	negative regulation of fibroblast proliferation
N	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
N	0048485	biological_process	sympathetic nervous system development
N	0048593	biological_process	camera-type eye morphogenesis
N	0048708	biological_process	astrocyte differentiation
N	0048709	biological_process	oligodendrocyte differentiation
N	0048712	biological_process	negative regulation of astrocyte differentiation
N	0048715	biological_process	negative regulation of oligodendrocyte differentiation
N	0048745	biological_process	smooth muscle tissue development
N	0048820	biological_process	hair follicle maturation
N	0048844	biological_process	artery morphogenesis
N	0048853	biological_process	forebrain morphogenesis
N	0050890	biological_process	cognition
N	0051402	biological_process	neuron apoptotic process
N	0060253	biological_process	negative regulation of glial cell proliferation
N	0060291	biological_process	long-term synaptic potentiation
N	0061534	biological_process	gamma-aminobutyric acid secretion, neurotransmission
N	0061535	biological_process	glutamate secretion, neurotransmission
N	0070372	biological_process	regulation of ERK1 and ERK2 cascade
N	0070662	biological_process	mast cell proliferation
N	0070667	biological_process	negative regulation of mast cell proliferation
N	0071887	biological_process	leukocyte apoptotic process
N	0072089	biological_process	stem cell proliferation
N	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
N	0097529	biological_process	myeloid leukocyte migration
N	0098597	biological_process	observational learning
N	0098793	cellular_component	presynapse
N	0098978	cellular_component	glutamatergic synapse
N	0099175	biological_process	regulation of postsynapse organization
N	1900148	biological_process	negative regulation of Schwann cell migration
N	1900271	biological_process	regulation of long-term synaptic potentiation
N	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
N	1904738	biological_process	vascular associated smooth muscle cell migration
N	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
N	1990874	biological_process	vascular associated smooth muscle cell proliferation
N	2000108	biological_process	positive regulation of leukocyte apoptotic process
N	2000647	biological_process	negative regulation of stem cell proliferation
N	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Functional Information from PROSITE/UniProt

site_id	PS00509
Number of Residues	15
Details	RAS_GTPASE_ACTIV_1 Ras GTPase-activating proteins domain signature. SaMFLRFINPAIVSP

Chain	Residue	Details
F	SER1407-PRO1421

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P97526

Chain	Residue	Details
F	ALA2
N	ALA2

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	SER864
N	SER864

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	SER876
N	SER876

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	SER2188
F	SER2521
N	SER2188
N	SER2521

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q04690

Chain	Residue	Details
F	SER2467
N	SER2467

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q04690

Chain	Residue	Details
F	THR2514
N	THR2514

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	SER2515
N	SER2515

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	SER2523
F	SER2597
F	SER2802
N	SER2523
N	SER2597
N	SER2802

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
F	SER2543
N	SER2543

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	THR2565
N	THR2565

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569

Chain	Residue	Details
F	SER2817
N	SER2817

---