6FB3
Teneurin 2 Partial Extracellular Domain
Summary for 6FB3
| Entry DOI | 10.2210/pdb6fb3/pdb |
| Descriptor | Teneurin-2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
| Functional Keywords | ttr, fibronectin, fn-plug, nhl, yd-repeat, antibiotic-binding, colicin, nuclease, cell surface receptor, latrophilin, glycoprotein, cell adhesion |
| Biological source | Gallus gallus (Chicken) |
| Total number of polymer chains | 4 |
| Total formula weight | 853679.91 |
| Authors | Jackson, V.A.,Carrasquero, M.,Lowe, E.D.,Seiradake, E. (deposition date: 2017-12-18, release date: 2018-03-28, Last modification date: 2024-11-06) |
| Primary citation | Jackson, V.A.,Meijer, D.H.,Carrasquero, M.,van Bezouwen, L.S.,Lowe, E.D.,Kleanthous, C.,Janssen, B.J.C.,Seiradake, E. Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction. Nat Commun, 9:1079-1079, 2018 Cited by PubMed Abstract: Teneurins are ancient cell-cell adhesion receptors that are vital for brain development and synapse organisation. They originated in early metazoan evolution through a horizontal gene transfer event when a bacterial YD-repeat toxin fused to a eukaryotic receptor. We present X-ray crystallography and cryo-EM structures of two Teneurins, revealing a ~200 kDa extracellular super-fold in which eight sub-domains form an intricate structure centred on a spiralling YD-repeat shell. An alternatively spliced loop, which is implicated in homophilic Teneurin interaction and specificity, is exposed and thus poised for interaction. The N-terminal side of the shell is 'plugged' via a fibronectin-plug domain combination, which defines a new class of YD proteins. Unexpectedly, we find that these proteins are widespread amongst modern bacteria, suggesting early metazoan receptor evolution from a distinct class of proteins, which today includes both bacterial proteins and eukaryotic Teneurins. PubMed: 29540701DOI: 10.1038/s41467-018-03460-0 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.38 Å) |
Structure validation
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