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1YY9
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BU of 1yy9 by Molmil
Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab Fab Heavy chain, ...
著者Li, S, Schmitz, K.R, Jeffrey, P.D, Wiltzius, J.J.W, Kussie, P, Ferguson, K.M.
登録日2005-02-24
公開日2005-04-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.605 Å)
主引用文献Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
Cancer Cell, 7, 2005
5CEV
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BU of 5cev by Molmil
ARGINASE FROM BACILLUS CALDEVELOX, L-LYSINE COMPLEX
分子名称: GUANIDINE, LYSINE, MANGANESE (II) ION, ...
著者Bewley, M.C, Jeffrey, P.D, Patchett, M.L, Kanyo, Z.F, Baker, E.N.
登録日1999-03-16
公開日1999-04-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures of Bacillus caldovelox arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and catalysis in the arginase superfamily.
Structure Fold.Des., 7, 1999
1BI8
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BU of 1bi8 by Molmil
MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURES CDK6-P19INK4D INHIBITOR COMPLEX
分子名称: CYCLIN-DEPENDENT KINASE 6, CYCLIN-DEPENDENT KINASE INHIBITOR
著者Russo, A.A, Tong, L, Lee, J.O, Jeffrey, P.D, Pavletich, N.P.
登録日1998-06-22
公開日1999-01-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Nature, 395, 1998
1BI7
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BU of 1bi7 by Molmil
MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX
分子名称: CYCLIN-DEPENDENT KINASE 6, MULTIPLE TUMOR SUPPRESSOR
著者Russo, A.A, Tong, L, Lee, J.O, Jeffrey, P.D, Pavletich, N.P.
登録日1998-06-22
公開日1999-01-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Nature, 395, 1998
4M9R
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BU of 4m9r by Molmil
Crystal structure of CED-3
分子名称: Cell death protein 3
著者Xu, Y, Jeffrey, P.D, Shi, Y.G.
登録日2013-08-15
公開日2013-10-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.656 Å)
主引用文献Mechanistic insights into CED-4-mediated activation of CED-3
Genes Dev., 27, 2013
2AYO
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BU of 2ayo by Molmil
Structure of USP14 bound to ubquitin aldehyde
分子名称: Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 14
著者Hu, M, Li, P, Jeffrey, P.D, Shi, Y.
登録日2005-09-07
公開日2005-10-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
Embo J., 24, 2005
2AYN
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BU of 2ayn by Molmil
Structure of USP14, a proteasome-associated deubiquitinating enzyme
分子名称: Ubiquitin carboxyl-terminal hydrolase 14
著者Hu, M, Li, P, Jeffrey, P.D, Shi, Y.
登録日2005-09-07
公開日2005-10-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
Embo J., 24, 2005
2CEV
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BU of 2cev by Molmil
ARGINASE FROM BACILLUS CALDEVELOX, NATIVE STRUCTURE AT PH 8.5
分子名称: GUANIDINE, MANGANESE (II) ION, PROTEIN (ARGINASE)
著者Bewley, M.C, Jeffrey, P.D, Patchett, M.L, Kanyo, Z.F, Baker, E.N.
登録日1999-03-10
公開日1999-04-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structures of Bacillus caldovelox arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and catalysis in the arginase superfamily.
Structure Fold.Des., 7, 1999
6CFI
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BU of 6cfi by Molmil
Crystal structure of Rad4-Rad23 bound to a 6-4 photoproduct UV lesion
分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*AP*GP*CP*(T64)P*TP*GP*GP*AP*TP*GP*TP*TP*GP*AP*GP*TP*CP*A)-3'), DNA repair protein RAD4, DNA('-D(*TP*TP*GP*AP*CP*TP*CP*AP*AP*CP*AP*TP*CP*CP*AP*AP*AP*GP*CP*TP*AP*CP*AP*A)-'), ...
著者Min, J, Jeffrey, P.D.
登録日2018-02-15
公開日2019-02-27
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.36241913 Å)
主引用文献Structure and mechanism of pyrimidine-pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex.
Nucleic Acids Res., 47, 2019
6D0H
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BU of 6d0h by Molmil
ParT: Prs ADP-ribosylating toxin bound to cognate antitoxin ParS
分子名称: GLYCEROL, ParS: COG5642 (DUF2384) antitoxin, ParT: COG5654 (RES domain) toxin
著者Piscotta, F.J, Jeffrey, P.D, Link, A.J.
登録日2018-04-10
公開日2019-01-09
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6D0I
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BU of 6d0i by Molmil
ParT: Prs ADP-ribosylating toxin bound to cognate antitoxin ParS. L48M ParT, SeMet-substituted complex.
分子名称: GLYCEROL, ParS: COG5642 (DUF2384) antitoxin fragment, ParT: COG5654 (RES domain) toxin
著者Piscotta, F.J, Jeffrey, P.D, Link, A.J.
登録日2018-04-10
公開日2019-01-09
最終更新日2019-01-23
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6E52
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BU of 6e52 by Molmil
Chimeric structure of Saccharomyces cerevisiae GCN4 leucine zipper fused to Staphylococcus aureus AgrC cytoplasmic histidine kinase module (dataset anisotropically truncated by STARANISO)
分子名称: Staphylococcus aureus AgrC histidine kinase module fused to Saccharomyces cerevisiae GCN4 leucine zipper
著者Xie, Q, Jeffrey, P.D, Muir, T.W.
登録日2018-07-19
公開日2019-02-27
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Identification of a Molecular Latch that Regulates Staphylococcal Virulence.
Cell Chem Biol, 26, 2019
6E95
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BU of 6e95 by Molmil
Chimeric structure of Saccharomyces cerevisiae GCN4 leucine zipper fused to Staphylococcus aureus AgrC cytoplasmic histidine kinase module (dataset isotropically truncated by HKL2000)
分子名称: Staphylococcus aureus AgrC histidine kinase module fused to Saccharomyces cerevisiae GCN4 leucine zipper
著者Xie, Q, Jeffrey, P.D, Muir, T.W.
登録日2018-07-31
公開日2019-02-27
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Identification of a Molecular Latch that Regulates Staphylococcal Virulence.
Cell Chem Biol, 26, 2019
2F1W
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BU of 2f1w by Molmil
Crystal structure of the TRAF-like domain of HAUSP/USP7
分子名称: CALCIUM ION, Ubiquitin carboxyl-terminal hydrolase 7
著者Hu, M, Gu, L, Jeffrey, P.D, Shi, Y.
登録日2005-11-15
公開日2006-02-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2F1S
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BU of 2f1s by Molmil
Crystal Structure of a Viral FLIP MC159
分子名称: Viral CASP8 and FADD-like apoptosis regulator
著者Li, F.-Y, Jeffrey, P.D, Yu, J.W, Shi, Y.
登録日2005-11-15
公開日2005-11-29
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal Structure of a Viral FLIP: INSIGHTS INTO FLIP-MEDIATED INHIBITION OF DEATH RECEPTOR SIGNALING.
J.Biol.Chem., 281, 2006
2F1Z
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BU of 2f1z by Molmil
Crystal structure of HAUSP
分子名称: Ubiquitin carboxyl-terminal hydrolase 7
著者Hu, M, Gu, L, Jeffrey, P.D, Shi, Y.
登録日2005-11-15
公開日2006-02-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2F1Y
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BU of 2f1y by Molmil
Crystal structure of the TRAF-like domain of HAUSP/USP7 bound to a MDM2 peptide
分子名称: HAUSP/USP7
著者Hu, M, Gu, L, Jeffrey, P.D, Shi, Y.
登録日2005-11-15
公開日2006-02-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2F1X
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BU of 2f1x by Molmil
Crystal structure of the TRAF-like domain of HAUSP/USP7 bound to a p53 peptide
分子名称: HAUSP/USP7
著者Hu, M, Gu, L, Jeffrey, P.D, Shi, Y.
登録日2005-11-15
公開日2006-02-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2HV6
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BU of 2hv6 by Molmil
Crystal structure of the phosphotyrosyl phosphatase activator
分子名称: MAGNESIUM ION, Protein phosphatase 2A, regulatory subunit B
著者Chao, Y, Jeffrey, P.D, Shi, Y.
登録日2006-07-27
公開日2006-08-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure and mechanism of the phosphotyrosyl phosphatase activator.
Mol.Cell, 23, 2006
1FBV
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BU of 1fbv by Molmil
STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES
分子名称: SIGNAL TRANSDUCTION PROTEIN CBL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ...
著者Zheng, N, Wang, P, Jeffrey, P.D, Pavletich, N.P.
登録日2000-07-17
公開日2000-08-30
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
Cell(Cambridge,Mass.), 102, 2000
1FQV
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BU of 1fqv by Molmil
Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex
分子名称: SKP1, SKP2
著者Schulman, B.A, Carrano, A.C, Jeffrey, P.D, Bowen, Z, Kinnucan, E.R, Finnin, M.S, Elledge, S.J, Harper, J.W, Pagano, M, Pavletich, N.P.
登録日2000-09-06
公開日2000-11-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Nature, 408, 2000
1FS2
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BU of 1fs2 by Molmil
INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX
分子名称: SKP1, SKP2
著者Schulman, B.A, Carrano, A.C, Jeffrey, P.D, Bowen, Z, Kinnucan, E.R.E, Finnin, M.S, Elledge, S.J, Harper, J.W, Pagano, M, Pavletich, N.P.
登録日2000-09-08
公開日2000-11-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Nature, 408, 2000
2IE3
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BU of 2ie3 by Molmil
Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins
分子名称: MANGANESE (II) ION, Protein Phosphatase 2, regulatory subunit A (PR 65), ...
著者Xing, Y, Xu, Y, Chen, Y, Jeffrey, P.D, Chao, Y, Shi, Y.
登録日2006-09-17
公開日2006-11-07
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
Cell(Cambridge,Mass.), 127, 2006
1FS1
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INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX
分子名称: CYCLIN A/CDK2-ASSOCIATED P19, CYCLIN A/CDK2-ASSOCIATED P45
著者Schulman, B.A, Carrano, A.C, Jeffrey, P.D, Bowen, Z, Kinnucan, E.R.E, Finnin, M.S, Elledge, S.J, Harper, J.W, Pagano, M, Pavletich, N.P.
登録日2000-09-08
公開日2000-11-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Nature, 408, 2000
2IE4
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Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid
分子名称: MANGANESE (II) ION, OKADAIC ACID, Protein Phosphatase 2, ...
著者Xing, Y, Xu, Y, Chen, Y, Jeffrey, P.D, Chao, Y, Shi, Y.
登録日2006-09-17
公開日2006-11-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
Cell(Cambridge,Mass.), 127, 2006

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