2F1X

Crystal structure of the TRAF-like domain of HAUSP/USP7 bound to a p53 peptide

Summary for 2F1X

• Entry DOI: 10.2210/pdb2f1x/pdb
• Related: 2F1W
• Descriptor: HAUSP/USP7 (2 entities in total)
• Functional Keywords: traf-like domain, p53 recognition, peptide binding, hausp, usp7, ubp, substrate recognition, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 2
• Total formula weight: 37413.37

Authors

Hu, M.,Gu, L.,Jeffrey, P.D.,Shi, Y. (deposition date: 2005-11-15, release date: 2006-02-07, Last modification date: 2023-08-23)

• Primary citation: Hu, M.,Gu, L.,Li, M.,Jeffrey, P.D.,Gu, W.,Shi, Y.; Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.; Plos Biol., 4:e27-e27, 2006; PubMed: 16402859; DOI: 10.1371/journal.pbio.0040027

Experimental method

X-RAY DIFFRACTION (2.3 Å)