4TN2
| NS5b in complex with lactam-thiophene carboxylic acids | 分子名称: | 3-[(2R)-2-cyclohexyl-5-oxopyrrolidin-1-yl]-5-phenylthiophene-2-carboxylic acid, Genome polyprotein | 著者 | Chopra, R. | 登録日 | 2014-06-02 | 公開日 | 2014-09-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors. Bioorg.Med.Chem.Lett., 24, 2014
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3SQF
| Crystal structure of monomeric M-PMV retroviral protease | 分子名称: | Protease | 著者 | Jaskolski, M, Kazmierczyk, M, Gilski, M, Krzywda, S, Pichova, I, Zabranska, H, Khatib, F, DiMaio, F, Cooper, S, Thompson, J, Popovic, Z, Baker, D, Group, Foldit Contenders | 登録日 | 2011-07-05 | 公開日 | 2011-09-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.6324 Å) | 主引用文献 | Crystal structure of a monomeric retroviral protease solved by protein folding game players. Nat.Struct.Mol.Biol., 18, 2011
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5GLA
| Crystal structure of the class A beta-lactamase PenL-tTR10 containing 10 residues insertion in omega-loop | 分子名称: | Beta-lactamase | 著者 | Choi, J.M, Yi, H, Kim, H.S, Lee, S.H. | 登録日 | 2016-07-10 | 公開日 | 2017-02-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A beta-lactamase, PenL Sci Rep, 6, 2016
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3SUP
| RB69 DNA Polymerase (Y567A) Ternary Complex with dCTP Opposite 2AP (GC rich sequence) | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*GP*CP*GP*CP*GP*GP*CP*GP*GP*CP*GP*(2DA))-3', 5'-D(P*CP*(2PR)P*TP*CP*GP*CP*CP*GP*CP*CP*GP*CP*GP*CP*GP*G)-3', ... | 著者 | Xia, S, Konigsberg, W.H, Wang, J. | 登録日 | 2011-07-11 | 公開日 | 2011-11-09 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Structure of the 2-Aminopurine-Cytosine Base Pair Formed in the Polymerase Active Site of the RB69 Y567A-DNA Polymerase. Biochemistry, 50, 2011
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5GL9
| Crystal structure of the class A beta-lactamase PenL | 分子名称: | Beta-lactamase, GLYCEROL | 著者 | Choi, J.M, Yi, H, Kim, H.S, Lee, S.H. | 登録日 | 2016-07-10 | 公開日 | 2017-02-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A beta-lactamase, PenL Sci Rep, 6, 2016
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7UOV
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7UOT
| Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 37.2D heavy chain (variable domain), ... | 著者 | Li, H, Saphire, E.O. | 登録日 | 2022-04-13 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus. Sci Transl Med, 14, 2022
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3G11
| Structure of E. coli FabF(C163Q) in complex with dihydrophenyl platensimycin | 分子名称: | 3-({3-[(1S,4S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxo-4-phenyldecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 著者 | Soisson, S.M, Parthasarathy, G. | 登録日 | 2009-01-29 | 公開日 | 2009-03-17 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Synthesis and biological evaluation of platensimycin analogs. Bioorg.Med.Chem.Lett., 19, 2009
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7VXY
| Zika virus NS2B/NS3 protease bZipro(C143S) in complex with D-RKOR | 分子名称: | Peptide inhibitor, Serine protease NS3, Serine protease subunit NS2B | 著者 | Xiong, Y.C, Cheng, F, Zhang, J.Y, Su, H.X, Hu, H.C, Zou, Y, Li, M.J, Xu, Y.C. | 登録日 | 2021-11-13 | 公開日 | 2022-09-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | Structure-based design of a novel inhibitor of the ZIKA virus NS2B/NS3 protease. Bioorg.Chem., 128, 2022
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3V6R
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8J1Z
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8SD3
| CryoEM structure of rat Kv2.1(1-598) wild type in nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1 | 著者 | Tan, X, Swartz, K.J. | 登録日 | 2023-04-06 | 公開日 | 2023-09-27 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Inactivation of the Kv2.1 channel through electromechanical coupling. Nature, 622, 2023
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8SDA
| CryoEM structure of rat Kv2.1(1-598) L403A mutant in nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1 | 著者 | Tan, X, Swartz, K.J. | 登録日 | 2023-04-06 | 公開日 | 2023-09-27 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Inactivation of the Kv2.1 channel through electromechanical coupling. Nature, 622, 2023
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7BED
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7BCY
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5T5G
| human SETD8 in complex with MS2177 | 分子名称: | 7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)-N-[5-(pyrrolidin-1-yl)pentyl]quinazolin-4-amine, N-lysine methyltransferase KMT5A, UNKNOWN ATOM OR ION | 著者 | Yu, W, Tempel, W, Babault, N, Ma, A, Butler, K.V, Jin, J, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2016-08-30 | 公開日 | 2016-09-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. J. Med. Chem., 59, 2016
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8JI0
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4IRS
| Structure of the mouse CD1d-PyrC-alpha-GalCer-iNKT TCR complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Nemcovic, M, Zajonc, D.M. | 登録日 | 2013-01-15 | 公開日 | 2013-09-04 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Enhanced TCR footprint by a novel glycolipid increases NKT-dependent tumor protection. J.Immunol., 191, 2013
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5GLB
| Crystal structure of the class A beta-lactamase PenL-tTR10 in complex with CBA | 分子名称: | Beta-lactamase, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE | 著者 | Choi, J.M, Yi, H, Kim, H.S, Lee, S.H. | 登録日 | 2016-07-10 | 公開日 | 2017-02-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A beta-lactamase, PenL Sci Rep, 6, 2016
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5OOG
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5ER1
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4AGW
| Discovery of a small molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromet hyl)phenyl}benzamide, GLYCEROL, ... | 著者 | Weisberg, E, Choi, H.G, Seeliger, M, Gray, N, Griffin, J.D. | 登録日 | 2012-02-01 | 公開日 | 2012-02-15 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of a Small-Molecule Type II Inhibitor of Wild-Type and Gatekeeper Mutants of Bcr-Abl, Pdgfralpha, Kit, and Src Kinases: Novel Type II Inhibitor of Gatekeeper Mutants. Blood, 115, 2010
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9F41
| Crystal structure of the NTD domain from S. cerevisia Niemann-Pick type C protein NCR1 with cholesterol bound | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHOLESTEROL, DI(HYDROXYETHYL)ETHER, ... | 著者 | Nel, L, Olesen, E, Frain, K.M, Pedersen, B.P. | 登録日 | 2024-04-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C 1-related protein To Be Published
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9F40
| Crystal structure of the NTD domain from S. cerevisia Niemann-Pick type C protein NCR1 with ergosterol bound | 分子名称: | ACETONITRILE, DI(HYDROXYETHYL)ETHER, ERGOSTEROL, ... | 著者 | Nel, L, Olesen, E, Frain, K.M, Pedersen, B.P. | 登録日 | 2024-04-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C 1-related protein To Be Published
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6CU6
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