5T5G
human SETD8 in complex with MS2177
Summary for 5T5G
Entry DOI | 10.2210/pdb5t5g/pdb |
Descriptor | N-lysine methyltransferase KMT5A, UNKNOWN ATOM OR ION, 7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)-N-[5-(pyrrolidin-1-yl)pentyl]quinazolin-4-amine, ... (4 entities in total) |
Functional Keywords | structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: Q9NQR1 |
Total number of polymer chains | 1 |
Total formula weight | 17223.47 |
Authors | Yu, W.,Tempel, W.,Babault, N.,Ma, A.,Butler, K.V.,Jin, J.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2016-08-30, release date: 2016-09-28, Last modification date: 2023-10-04) |
Primary citation | Butler, K.V.,Ma, A.,Yu, W.,Li, F.,Tempel, W.,Babault, N.,Pittella-Silva, F.,Shao, J.,Wang, J.,Luo, M.,Vedadi, M.,Brown, P.J.,Arrowsmith, C.H.,Jin, J. Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. J. Med. Chem., 59:9881-9889, 2016 Cited by PubMed: 27804297DOI: 10.1021/acs.jmedchem.6b01244 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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