5T5G
human SETD8 in complex with MS2177
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | N-lysine methyltransferase KMT5A | polymer | 148 | 16780.9 | 1 | UniProt (Q9NQR1) Pfam (PF00856) | Homo sapiens (Human) | H4-K20-HMTase KMT5A,Histone-lysine N-methyltransferase KMT5A,Lysine N-methyltransferase 5A,Lysine-specific methylase 5A,PR/SET domain-containing protein 07,PR/SET07,SET domain-containing protein 8 |
| 2 | B, C, D, E, F... (A) | UNKNOWN ATOM OR ION | non-polymer | 6 | Chemie (UNX) | ||||
| 3 | H (A) | 7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)-N-[5-(pyrrolidin-1-yl)pentyl]quinazolin-4-amine | non-polymer | 442.6 | 1 | Chemie (75P) | |||
| 4 | I (A) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A: 234 - 380 (UniProt: Q9NQR1)
| PDB | External Database | Details |
|---|---|---|
| Gly 233 | - | expression tag |
| Ser 343 | Cys 343 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 16780.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 442.6 | |
| All* | Total formula weight | 17223.5 |
