5JFG
 
 | | Structure of humanised RadA-mutant humRadA22F in complex with peptide FHTA | | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, DNA repair and recombination protein RadA, ... | | 著者 | Fischer, G, Marsh, M, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M. | | 登録日 | 2016-04-19 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Humanisation of RadA from Pyrococcus furiosus
To Be Published
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5I04
 | | Crystal structure of the orphan region of human endoglin/CD105 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Maltose-binding periplasmic protein,Endoglin, TRIETHYLENE GLYCOL, ... | | 著者 | Saito, T, Bokhove, M, de Sanctis, D, Jovine, L. | | 登録日 | 2016-02-03 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1.
Cell Rep, 19, 2017
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5JZD
 | | A re-refinement of the isochorismate synthase EntC | | 分子名称: | (5S,6S)-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohexa-1,3-diene-1-carboxylic acid, Isochorismate synthase EntC, MAGNESIUM ION | | 著者 | Meneely, K.M, Lamb, A.L. | | 登録日 | 2016-05-16 | | 公開日 | 2016-07-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.303 Å) | | 主引用文献 | An Open and Shut Case: The Interaction of Magnesium with MST Enzymes.
J.Am.Chem.Soc., 138, 2016
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3KMB
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4KMB
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6QMH
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3SGN
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3SGM
 | | Bromoderivative-2 of amyloid-related segment of alphaB-crystallin residues 90-100 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Alpha-crystallin B chain | | 著者 | Laganowsky, A, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2011-06-15 | | 公開日 | 2012-03-21 | | 実験手法 | X-RAY DIFFRACTION (1.7006 Å) | | 主引用文献 | Atomic view of a toxic amyloid small oligomer.
Science, 335, 2012
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3SGR
 | | Tandem repeat of amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Tandem repeat of amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L | | 著者 | Laganowsky, A, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2011-06-15 | | 公開日 | 2012-03-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Atomic view of a toxic amyloid small oligomer.
Science, 335, 2012
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5N8C
 | | Crystal structure of Pseudomonas aeruginosa LpxC complexed with inhibitor | | 分子名称: | (2~{S})-3-azanyl-2-[[(1~{R})-5-[2-[4-[[2-(hydroxymethyl)imidazol-1-yl]methyl]phenyl]ethynyl]-2,3-dihydro-1~{H}-inden-1-yl]amino]-3-methyl-~{N}-oxidanyl-butanamide, CHLORIDE ION, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ... | | 著者 | Cross, J.B, Ryan, M.D, Zhang, J, Cheng, R.K, Wood, M, Andersen, O.A, Brooks, M, Kwong, J, Barker, J. | | 登録日 | 2017-02-23 | | 公開日 | 2017-03-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-based discovery of LpxC inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
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3SGO
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6QMF
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3SGS
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6QMI
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3SGP
 | | Amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Alpha-crystallin B chain | | 著者 | Laganowsky, A, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2011-06-15 | | 公開日 | 2012-03-21 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.4016 Å) | | 主引用文献 | Atomic view of a toxic amyloid small oligomer.
Science, 335, 2012
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6QMG
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1B6F
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2KMB
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5OU2
 | | M. thermoresistible IMPDH in complex with IMP and Compound 2 (NMR744) | | 分子名称: | 4-(4-bromophenyl)-1H-imidazole, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase | | 著者 | Ascher, D.B, Pacitto, A, Blundell, T.L. | | 登録日 | 2017-08-23 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.
J. Med. Chem., 61, 2018
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5NZ1
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5NZ0
 | | Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with linezolid | | 分子名称: | 1,2-ETHANEDIOL, HTH-type transcriptional regulator EthR, N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide | | 著者 | Blaszczyk, M, Mendes, V, Nikiforov, P.O, Blundell, T.L. | | 登録日 | 2017-05-12 | | 公開日 | 2018-05-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.825 Å) | | 主引用文献 | The antibiotics linezolid and sutezolid are ligands for Mycobacterium tuberculosis EthR
To Be Published
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5OU1
 | | M. thermoresistible IMPDH in complex with IMP and Compound 1 (7759844) | | 分子名称: | (2~{S})-~{N}-(4-iodophenyl)-2-(4-methoxyphenoxy)propanamide, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase | | 著者 | Ascher, D.B, Pacitto, A, Blundell, T.L. | | 登録日 | 2017-08-23 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.
J. Med. Chem., 61, 2018
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5OU3
 | | M. thermoresistible IMPDH in complex with IMP and Compound 31 (AT080) | | 分子名称: | (2~{S})-~{N}-[5-(4-bromophenyl)-1~{H}-imidazol-2-yl]-2-[4-(1-methylimidazol-4-yl)phenoxy]propanamide, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase | | 著者 | Ascher, D.B, Pacitto, A, Blundell, T.L. | | 登録日 | 2017-08-23 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.
J. Med. Chem., 61, 2018
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