6QMF
Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis in complex with 5-[3-(1H-indol-3-yl)propoxy]-1-phenyl-1H-pyrazole-4-carboxylic acid at 1.8A resolution.
Replaces: 6G7USummary for 6QMF
Entry DOI | 10.2210/pdb6qmf/pdb |
Descriptor | Phosphopantetheine adenylyltransferase, 3-indol-1-ylpropanoic acid, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | coad, ppat, transferase, complex |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 1 |
Total formula weight | 18059.73 |
Authors | Blaszczyk, M.,Blundell, T.L. (deposition date: 2019-02-07, release date: 2020-02-26, Last modification date: 2024-01-24) |
Primary citation | Blaszczyk, M.,El Bakali, J.,Boland, J.A.,Spry, C.,Dias, M.,Blundell, T.L.,Abel, C. Fragment linking applied to the discovery of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase inhibitors To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.771 Å) |
Structure validation
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