6QMF

Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis in complex with 5-[3-(1H-indol-3-yl)propoxy]-1-phenyl-1H-pyrazole-4-carboxylic acid at 1.8A resolution.

Replaces:  6G7U

Summary for 6QMF

• Entry DOI: 10.2210/pdb6qmf/pdb
• Descriptor: Phosphopantetheine adenylyltransferase, 3-indol-1-ylpropanoic acid, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: coad, ppat, transferase, complex
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 1
• Total formula weight: 18059.73

Authors

Blaszczyk, M.,Blundell, T.L. (deposition date: 2019-02-07, release date: 2020-02-26, Last modification date: 2024-01-24)

• Primary citation: Blaszczyk, M.,El Bakali, J.,Boland, J.A.,Spry, C.,Dias, M.,Blundell, T.L.,Abel, C.; Fragment linking applied to the discovery of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.771 Å)