5OU3

M. thermoresistible IMPDH in complex with IMP and Compound 31 (AT080)

Summary for 5OU3

Entry DOI	10.2210/pdb5ou3/pdb
Descriptor	Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, (2~{S})-~{N}-[5-(4-bromophenyl)-1~{H}-imidazol-2-yl]-2-[4-(1-methylimidazol-4-yl)phenoxy]propanamide, ... (4 entities in total)
Functional Keywords	complex, fragment, impdh, oxidoreductase
Biological source	Mycobacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316) More
Total number of polymer chains	1
Total formula weight	40669.01
Authors	Ascher, D.B.,Pacitto, A.,Blundell, T.L. (deposition date: 2017-08-23, release date: 2018-03-28, Last modification date: 2019-10-16)
Primary citation	Trapero, A.,Pacitto, A.,Singh, V.,Sabbah, M.,Coyne, A.G.,Mizrahi, V.,Blundell, T.L.,Ascher, D.B.,Abell, C. Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis. J. Med. Chem., 61:2806-2822, 2018 Cited by PubMed: 29547284 DOI: 10.1021/acs.jmedchem.7b01622 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation