3SGN

Bromoderivative-8 of amyloid-related segment of alphaB-crystallin residues 90-100

Summary for 3SGN

Related3SGM 3SGO 3SGP 3SGR 3SGS
DescriptorAlpha-crystallin B chain (2 entities in total)
Functional Keywordsamyloid, amyloid oligomer, beta cylindrin, protein fibril
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P02511
Total number of polymer chains2
Total molecular weight2554.7
Authors
Laganowsky, A.,Sawaya, M.R.,Cascio, D.,Eisenberg, D. (deposition date: 2011-06-15, release date: 2012-03-21)
Primary citation
Laganowsky, A.,Liu, C.,Sawaya, M.R.,Whitelegge, J.P.,Park, J.,Zhao, M.,Pensalfini, A.,Soriaga, A.B.,Landau, M.,Teng, P.K.,Cascio, D.,Glabe, C.,Eisenberg, D.
Atomic view of a toxic amyloid small oligomer.
Science, 335:1228-1231, 2012
PubMed: 22403391 (PDB entries with the same primary citation)
DOI: 10.1126/science.1213151
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.807 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2190016.7%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3sgn
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Molmil generated image of 3sgn
rotated about x axis by 90°
Molmil generated image of 3sgn
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 3sgn
no rotation
Molmil generated image of 3sgn
rotated about x axis by 90°
Molmil generated image of 3sgn
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3sgn.pdb1.gz [9.52 KB])