Crystal structure of the orphan region of human endoglin/CD105

Summary for 5I04

Related5HZW 5HZV 5I05
DescriptorMaltose-binding periplasmic protein,Endoglin, N-ACETYL-D-GLUCOSAMINE, MALTOSE, ... (5 entities in total)
Functional Keywordsorphan domain, angiogenesis, glycoprotein, receptor, signaling protein
Biological sourceEscherichia coli K-12
Cellular locationMembrane; Single-pass type I membrane protein P17813
Total number of polymer chains1
Total molecular weight76268.36
Saito, T.,Bokhove, M.,de Sanctis, D.,Jovine, L. (deposition date: 2016-02-03, release date: 2017-06-07, Last modification date: 2017-09-06)
Primary citation
Saito, T.,Bokhove, M.,Croci, R.,Zamora-Caballero, S.,Han, L.,Letarte, M.,de Sanctis, D.,Jovine, L.
Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1.
Cell Rep, 19:1917-1928, 2017
PubMed: 28564608 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2017.05.011
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.263300.4%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report