7CKW
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![BU of 7ckw by Molmil](/molmil-images/mine/7ckw) | Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex | 分子名称: | (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | 著者 | Yan, W, Shao, W. | 登録日 | 2020-07-20 | 公開日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell, 184, 2021
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7CKZ
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![BU of 7ckz by Molmil](/molmil-images/mine/7ckz) | Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling complex | 分子名称: | 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ... | 著者 | Yan, W, Shao, Z. | 登録日 | 2020-07-20 | 公開日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell, 184, 2021
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6KIN
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![BU of 6kin by Molmil](/molmil-images/mine/6kin) | Crystal structure of the tri-functional malyl-CoA lyase from Roseiflexus castenholzii | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, HpcH/HpaI aldolase | 著者 | Tang, W.R, Zhang, C.Y, Wang, C, Xu, X.L. | 登録日 | 2019-07-19 | 公開日 | 2019-09-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.527 Å) | 主引用文献 | The C-terminal domain conformational switch revealed by the crystal structure of malyl-CoA lyase from Roseiflexus castenholzii. Biochem.Biophys.Res.Commun., 518, 2019
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6A7A
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![BU of 6a7a by Molmil](/molmil-images/mine/6a7a) | AKR1C1 complexed with new inhibitor with novel scaffold | 分子名称: | (4R)-6-amino-4-(4-hydroxy-3-methoxy-5-nitrophenyl)-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Zheng, X, Zhao, Y, Zhang, H, Chen, Y. | 登録日 | 2018-07-02 | 公開日 | 2019-07-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors. Bioorg.Med.Chem., 26, 2018
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7P1K
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![BU of 7p1k by Molmil](/molmil-images/mine/7p1k) | Cryo EM structure of bison NHA2 in nano disc structure | 分子名称: | CHOLESTEROL HEMISUCCINATE, Phosphatidylinositol, mitochondrial sodium/hydrogen exchanger 9B2 | 著者 | Matsuoka, R, Fudim, R, Jung, S, Drew, D. | 登録日 | 2021-07-01 | 公開日 | 2022-01-26 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Structure, mechanism and lipid-mediated remodeling of the mammalian Na + /H + exchanger NHA2. Nat.Struct.Mol.Biol., 29, 2022
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7P1J
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![BU of 7p1j by Molmil](/molmil-images/mine/7p1j) | Cryo EM structure of bison NHA2 in detergent structure | 分子名称: | mitochondrial sodium/hydrogen exchanger 9B2 | 著者 | Matsuoka, R, Fudim, R, Jung, S, Drew, D. | 登録日 | 2021-07-01 | 公開日 | 2022-01-26 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Structure, mechanism and lipid-mediated remodeling of the mammalian Na + /H + exchanger NHA2. Nat.Struct.Mol.Biol., 29, 2022
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7P1I
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![BU of 7p1i by Molmil](/molmil-images/mine/7p1i) | Cryo EM structure of bison NHA2 in detergent and N-terminal extension helix | 分子名称: | mitochondrial sodium/hydrogen exchanger 9B2 | 著者 | Matsuoka, R, Fudim, R, Jung, S, Drew, D. | 登録日 | 2021-07-01 | 公開日 | 2022-01-26 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Structure, mechanism and lipid-mediated remodeling of the mammalian Na + /H + exchanger NHA2. Nat.Struct.Mol.Biol., 29, 2022
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6UQC
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![BU of 6uqc by Molmil](/molmil-images/mine/6uqc) | Mouse IgG2a Bispecific Fc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wang, F, Tsai, J.C, Davis, J.H, West, S.M, Strop, P. | 登録日 | 2019-10-18 | 公開日 | 2020-01-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models. Mabs, 12, 2019
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8ITF
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![BU of 8itf by Molmil](/molmil-images/mine/8itf) | Cryo-EM structure of the DMCHA-bound mTAAR9-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | 登録日 | 2023-03-22 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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6KOL
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![BU of 6kol by Molmil](/molmil-images/mine/6kol) | Crystal structure of auracyanin from photosynthetic bacterium Roseiflexus castenholzii | 分子名称: | Blue (Type 1) copper domain protein, CHLORIDE ION, COPPER (II) ION | 著者 | Wang, C, Zhang, C.Y, Min, Z.Z, Xin, Y.Y, Xu, X.L. | 登録日 | 2019-08-12 | 公開日 | 2020-01-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.211 Å) | 主引用文献 | Structural basis underlying the electron transfer features of a blue copper protein auracyanin from the photosynthetic bacterium Roseiflexus castenholzii. Photosyn. Res., 143, 2020
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6L9S
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![BU of 6l9s by Molmil](/molmil-images/mine/6l9s) | Crystal structure of Na-dithionite reduced auracyanin from photosynthetic bacterium Roseiflexus castenholzii | 分子名称: | Blue (Type 1) copper domain protein, COPPER (I) ION | 著者 | Wang, C, Zhang, C.Y, Min, Z.Z, Xu, X.L. | 登録日 | 2019-11-10 | 公開日 | 2020-01-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis underlying the electron transfer features of a blue copper protein auracyanin from the photosynthetic bacterium Roseiflexus castenholzii. Photosyn. Res., 143, 2020
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7VUZ
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![BU of 7vuz by Molmil](/molmil-images/mine/7vuz) | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2 | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VV4
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7VDM
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7VV5
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![BU of 7vv5 by Molmil](/molmil-images/mine/7vv5) | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1 | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VDL
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7VDH
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![BU of 7vdh by Molmil](/molmil-images/mine/7vdh) | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2 | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-09-07 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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5I3O
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![BU of 5i3o by Molmil](/molmil-images/mine/5i3o) | Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor | 分子名称: | BMP-2-inducible protein kinase, N-(6-{3-[(dimethylsulfamoyl)amino]phenyl}-1H-indazol-3-yl)cyclopropanecarboxamide, SULFATE ION | 著者 | Counago, R.M, Sorrell, F.J, Krojer, T, Savitsky, P, Elkins, J.M, Axtman, A, Drewry, D, Wells, C, Zhang, C, Zuercher, W, Willson, T.M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Arruda, P, Gileadi, O, Structural Genomics Consortium (SGC) | 登録日 | 2016-02-10 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor To Be Published
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7VV0
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7VV6
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![BU of 7vv6 by Molmil](/molmil-images/mine/7vv6) | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80 (local) | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Mas-related G-protein coupled receptor member X2 | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VUY
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7VV3
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5I3R
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![BU of 5i3r by Molmil](/molmil-images/mine/5i3r) | Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor | 分子名称: | BMP-2-inducible protein kinase, N-[6-(3-{[(cyclopropylmethyl)sulfonyl]amino}phenyl)-1H-indazol-3-yl]cyclopropanecarboxamide, PHOSPHATE ION | 著者 | Counago, R.M, Sorrell, F.J, Krojer, T, Savitsky, P, Elkins, J.M, Axtman, A, Drewry, D, Wells, C, Zhang, C, Zuercher, W, Willson, T.M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Arruda, P, Gileadi, O, Structural Genomics Consortium (SGC) | 登録日 | 2016-02-10 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor To Be Published
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6P7G
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![BU of 6p7g by Molmil](/molmil-images/mine/6p7g) | The co-crystal structure of BRAF(V600E) with PHI1 | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide, Serine/threonine-protein kinase B-raf | 著者 | Agianian, B, Gavathiotis, E. | 登録日 | 2019-06-05 | 公開日 | 2020-09-23 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Inhibitors of BRAF dimers using an allosteric site. Nat Commun, 11, 2020
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2GFX
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