6UQC

Mouse IgG2a Bispecific Fc

Summary for 6UQC

• Entry DOI: 10.2210/pdb6uqc/pdb
• Descriptor: Ig gamma-2A chain C region, membrane-bound form, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: bispecific, electrostatic steering, fc, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 4
• Total formula weight: 100889.09

Authors

Wang, F.,Tsai, J.C.,Davis, J.H.,West, S.M.,Strop, P. (deposition date: 2019-10-18, release date: 2020-01-01, Last modification date: 2023-10-11)

• Primary citation: Wang, F.,Tsai, J.C.,Davis, J.H.,Chau, B.,Dong, J.,West, S.M.,Hogan, J.M.,Wheeler, M.L.,Bee, C.,Morishige, W.,Cayton, T.,David-Brown, D.,Zhang, C.,Kozhich, A.,Sproul, T.,Dollinger, G.,Rajpal, A.,Strop, P.; Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models.; Mabs, 12:1685350-1685350, 2019; PubMed: 31856660; DOI: 10.1080/19420862.2019.1685350

Experimental method

X-RAY DIFFRACTION (1.87 Å)