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7V68
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BU of 7v68 by Molmil
An Agonist and PAM-bound Class A GPCR with Gi protein complex structure
分子名称: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Wang, J.J, Wu, L.J, Wu, M, Hua, T, Liu, Z.J, Wang, T.
登録日2021-08-20
公開日2022-05-11
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.
Nat Commun, 13, 2022
7DBI
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BU of 7dbi by Molmil
Crystal structure of the peroxisomal acyl-CoA hydrolase MpaH
分子名称: acyl-CoA hydrolase MpaH'
著者Li, S.Y, You, C.
登録日2020-10-20
公開日2021-04-28
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Structural basis for substrate specificity of the peroxisomal acyl-CoA hydrolase MpaH' involved in mycophenolic acid biosynthesis.
Febs J., 288, 2021
7DBL
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BU of 7dbl by Molmil
Acyl-CoA hydrolase MpaH' mutant S139A in complex with MPA
分子名称: MYCOPHENOLIC ACID, acyl-CoA hydrolase MpaH'
著者Li, S.Y, You, C.
登録日2020-10-20
公開日2021-04-28
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structural basis for substrate specificity of the peroxisomal acyl-CoA hydrolase MpaH' involved in mycophenolic acid biosynthesis.
Febs J., 288, 2021
5ZQ8
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BU of 5zq8 by Molmil
Crystal structure of spRlmCD with U747 stemloop RNA
分子名称: NICKEL (II) ION, RNA (5'-R(*CP*CP*GP*UP*(MUM)P*GP*AP*AP*AP*AP*GP*G)-3'), S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Jiang, Y.Y, Yu, H.L.
登録日2018-04-17
公開日2018-10-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD
PLoS Pathog., 14, 2018
6AAU
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BU of 6aau by Molmil
Solution Structure for m62A helix 45 in 3' end of 12S rRNA
分子名称: RNA (24-mer)
著者Liu, X, Wu, P.
登録日2018-07-19
公開日2019-06-05
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function.
Nucleic Acids Res., 47, 2019
7W0L
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BU of 7w0l by Molmil
Cryo-EM structure of a dimeric GPCR-Gi complex with small molecule
分子名称: (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Yue, Y, Liu, L.E, Wu, L.J, Xu, F, Hanson, M.
登録日2021-11-18
公開日2022-07-27
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.57 Å)
主引用文献Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
7W0O
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Cryo-EM structure of a monomeric GPCR-Gi complex with peptide
分子名称: Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M.
登録日2021-11-18
公開日2022-07-27
実験手法ELECTRON MICROSCOPY (3.78 Å)
主引用文献Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
7W0M
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BU of 7w0m by Molmil
Cryo-EM structure of a monomeric GPCR-Gi complex with small molecule
分子名称: (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M.
登録日2021-11-18
公開日2022-07-27
実験手法ELECTRON MICROSCOPY (3.71 Å)
主引用文献Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
7W0P
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BU of 7w0p by Molmil
Cryo-EM structure of a GPCR-Gi complex with peptide
分子名称: Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M.
登録日2021-11-18
公開日2022-07-27
実験手法ELECTRON MICROSCOPY (3.16 Å)
主引用文献Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
4IKP
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BU of 4ikp by Molmil
Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin
分子名称: (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, GLYCEROL, Histone-arginine methyltransferase CARM1, ...
著者Dong, A, Dombrovski, L, He, H, Ibanez, G, Wernimont, A, Zheng, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Luo, M, Wu, H, Structural Genomics Consortium (SGC)
登録日2012-12-27
公開日2013-02-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.
Elife, 8, 2019
3SMR
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BU of 3smr by Molmil
Crystal structure of human WD repeat domain 5 with compound
分子名称: 1,2-ETHANEDIOL, 2-chloro-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ...
著者Dong, A, Dombrovski, L, Wasney, G.A, Tempel, W, Senisterra, G, Bolshan, Y, Smil, D, Nguyen, K.T, Hajian, T, Poda, G, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Brown, P.J, Schapira, M, Arrowsmith, C.H, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC)
登録日2011-06-28
公開日2011-08-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Biochem. J., 449, 2013
7W0N
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BU of 7w0n by Molmil
Cryo-EM structure of a dimeric GPCR-Gi complex with peptide
分子名称: Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, F, Yue, Y, Wu, L.J, Liu, L.E, Hanson, M.
登録日2021-11-18
公開日2022-07-27
実験手法ELECTRON MICROSCOPY (4.21 Å)
主引用文献Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
4I9U
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BU of 4i9u by Molmil
Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256
分子名称: 6-({2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl}sulfanyl)pyridine-3-carboxylic acid, L-lactate dehydrogenase A chain
著者Zhou, T, Kohlmann, A, Stephan, Z.G, Commodore, L, Greenfield, M.T, Zhu, X, Dalgarno, D.C.
登録日2012-12-05
公開日2013-01-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.
J.Med.Chem., 56, 2013
4JLG
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BU of 4jlg by Molmil
SETD7 in complex with inhibitor (R)-PFI-2 and S-adenosyl-methionine
分子名称: 8-fluoro-N-{(2R)-1-oxo-1-(pyrrolidin-1-yl)-3-[3-(trifluoromethyl)phenyl]propan-2-yl}-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, ...
著者Dong, A, Wu, H, Zeng, H, El Bakkouri, M, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
登録日2013-03-12
公開日2013-04-17
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.896 Å)
主引用文献(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Proc.Natl.Acad.Sci.USA, 111, 2014
4L0K
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BU of 4l0k by Molmil
Crystal structure of a type II restriction endonuclease
分子名称: DraIII
著者Zhuo, W, Ge, J, Yang, M.
登録日2013-05-31
公開日2014-05-14
実験手法X-RAY DIFFRACTION (2.328 Å)
主引用文献Elimination of inter-domain interactions increases the cleavage fidelity of the restriction endonuclease DraIII.
Protein Cell, 5, 2014
7W6K
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BU of 7w6k by Molmil
Cryo-EM structure of GmALMT12/QUAC1 anion channel
分子名称: GmALMT12/QUAC1
著者Qin, L, Tang, L.H, Xu, J.S, Zhang, X.H, Zhu, Y, Sun, F, Su, M, Zhai, Y.J, Chen, Y.H.
登録日2021-12-01
公開日2022-03-16
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structure and electrophysiological characterization of ALMT from Glycine max reveal a previously uncharacterized class of anion channels.
Sci Adv, 8, 2022
7ENQ
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BU of 7enq by Molmil
Crystal structure of human NAMPT in complex with compound NAT
分子名称: 2-(2-~{tert}-butylphenoxy)-~{N}-(4-hydroxyphenyl)ethanamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION
著者Wang, G, Wu, C, Liu, M, Yao, H, Li, C, Wang, L, Tang, Y.
登録日2021-04-19
公開日2022-05-04
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.204966 Å)
主引用文献Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity.
Cell Res., 32, 2022
3UR4
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BU of 3ur4 by Molmil
Crystal structure of human WD repeat domain 5 with compound
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ...
著者Dong, A, Dombrovski, L, Senisterra, G, Wernimont, A, Wasney, G.A, Allali Hassani, A, Nguyen, K.T, Smil, D, Bolshan, Y, Hajian, T, Poda, G, Chau, I, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC)
登録日2011-11-21
公開日2011-12-14
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Biochem. J., 449, 2013
4LRV
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BU of 4lrv by Molmil
Crystal structure of DndE from Escherichia coli B7A involved in DNA phosphorothioation modification
分子名称: DNA sulfur modification protein DndE
著者Hu, W, Wang, C.K, Liang, J.D, Zhang, T.L, Yang, M, Hu, Z.P, Wang, Z.J, Lan, W.X, Wu, H.M, Ding, J.P, Wu, G, Deng, Z.X, Cao, C.
登録日2013-07-21
公開日2013-08-28
最終更新日2013-09-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural insights into DndE from Escherichia coli B7A involved in DNA phosphorothioation modification
Cell Res., 22, 2012
4MI0
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BU of 4mi0 by Molmil
Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2)
分子名称: Histone-lysine N-methyltransferase EZH2, UNKNOWN ATOM OR ION, ZINC ION
著者Dong, A, Zeng, H, He, H, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC)
登録日2013-08-30
公開日2013-09-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.
Plos One, 8, 2013
7CKK
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BU of 7ckk by Molmil
Structural complex of FTO bound with Dac51
分子名称: 2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino}-N-hydroxybenzamide, Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE
著者Yang, C, Gan, J.
登録日2020-07-17
公開日2021-07-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance.
Cell Metab., 33, 2021
7DMP
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BU of 7dmp by Molmil
Mouse radial spoke complex
分子名称: Radial spoke head 1 homolog, Radial spoke head protein 4 homolog A, Radial spoke head protein 9 homolog
著者Zheng, W, Cong, Y.
登録日2020-12-05
公開日2021-07-21
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM
Proc.Natl.Acad.Sci.USA, 118, 2021
7K5C
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BU of 7k5c by Molmil
Structure of T7 DNA ejectosome periplasmic tunnel
分子名称: Internal virion protein gp15, Peptidoglycan transglycosylase gp16
著者Swanson, N, Cingolani, G, Pumroy, R.
登録日2020-09-16
公開日2021-07-28
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Cryo-EM structure of the periplasmic tunnel of T7 DNA-ejectosome at 2.7 angstrom resolution.
Mol.Cell, 81, 2021
4FMU
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BU of 4fmu by Molmil
Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF
分子名称: (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-(propylamino)hexanoic acid, Histone-lysine N-methyltransferase SETD2, UNKNOWN ATOM OR ION, ...
著者Dong, A, Zeng, H, Ibanez, G, Zheng, W, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Luo, M, Wu, H, Structural Genomics Consortium (SGC)
登録日2012-06-18
公開日2012-09-05
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2.
J.Am.Chem.Soc., 134, 2012
7DTK
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BU of 7dtk by Molmil
Crystal structure of the RecA1 domain of RNA helicase CGH-1 in C. elegans
分子名称: ATP-dependent RNA helicase cgh-1, GLYCEROL
著者Hong, J.J, Lv, M.Q, Zhang, Y.
登録日2021-01-05
公開日2021-03-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.849 Å)
主引用文献Structural and biochemical insights into the recognition of RNA helicase CGH-1 by CAR-1 in C. elegans.
Biochem.Biophys.Res.Commun., 549, 2021

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