7ENQ

Crystal structure of human NAMPT in complex with compound NAT

Summary for 7ENQ

Entry DOI	10.2210/pdb7enq/pdb
Descriptor	Nicotinamide phosphoribosyltransferase, 2-(2-~{tert}-butylphenoxy)-~{N}-(4-hydroxyphenyl)ethanamide, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	nampt, nat, nad, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	227462.52
Authors	Wang, G.,Wu, C.,Liu, M.,Yao, H.,Li, C.,Wang, L.,Tang, Y. (deposition date: 2021-04-19, release date: 2022-05-04, Last modification date: 2023-11-29)
Primary citation	Yao, H.,Liu, M.,Wang, L.,Zu, Y.,Wu, C.,Li, C.,Zhang, R.,Lu, H.,Li, F.,Xi, S.,Chen, S.,Gu, X.,Liu, T.,Cai, J.,Wang, S.,Yang, M.,Xing, G.G.,Xiong, W.,Hua, L.,Tang, Y.,Wang, G. Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. Cell Res., 32:570-584, 2022 Cited by PubMed: 35459935 DOI: 10.1038/s41422-022-00651-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.20496616708 Å)

Structure validation