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7ENQ

Crystal structure of human NAMPT in complex with compound NAT

Functional Information from GO Data
ChainGOidnamespacecontents
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0007165biological_processsignal transduction
A0007267biological_processcell-cell signaling
A0007623biological_processcircadian rhythm
A0008284biological_processpositive regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0009435biological_processNAD biosynthetic process
A0016607cellular_componentnuclear speck
A0016757molecular_functionglycosyltransferase activity
A0019363biological_processpyridine nucleotide biosynthetic process
A0030054cellular_componentcell junction
A0032922biological_processcircadian regulation of gene expression
A0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
A0042802molecular_functionidentical protein binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0047280molecular_functionnicotinamide phosphoribosyltransferase activity
A0048511biological_processrhythmic process
A0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
A0060612biological_processadipose tissue development
A0070062cellular_componentextracellular exosome
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0007165biological_processsignal transduction
B0007267biological_processcell-cell signaling
B0007623biological_processcircadian rhythm
B0008284biological_processpositive regulation of cell population proliferation
B0008286biological_processinsulin receptor signaling pathway
B0009435biological_processNAD biosynthetic process
B0016607cellular_componentnuclear speck
B0016757molecular_functionglycosyltransferase activity
B0019363biological_processpyridine nucleotide biosynthetic process
B0030054cellular_componentcell junction
B0032922biological_processcircadian regulation of gene expression
B0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
B0042802molecular_functionidentical protein binding
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0047280molecular_functionnicotinamide phosphoribosyltransferase activity
B0048511biological_processrhythmic process
B0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
B0060612biological_processadipose tissue development
B0070062cellular_componentextracellular exosome
C0005125molecular_functioncytokine activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0007165biological_processsignal transduction
C0007267biological_processcell-cell signaling
C0007623biological_processcircadian rhythm
C0008284biological_processpositive regulation of cell population proliferation
C0008286biological_processinsulin receptor signaling pathway
C0009435biological_processNAD biosynthetic process
C0016607cellular_componentnuclear speck
C0016757molecular_functionglycosyltransferase activity
C0019363biological_processpyridine nucleotide biosynthetic process
C0030054cellular_componentcell junction
C0032922biological_processcircadian regulation of gene expression
C0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
C0042802molecular_functionidentical protein binding
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0047280molecular_functionnicotinamide phosphoribosyltransferase activity
C0048511biological_processrhythmic process
C0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
C0060612biological_processadipose tissue development
C0070062cellular_componentextracellular exosome
D0005125molecular_functioncytokine activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0007165biological_processsignal transduction
D0007267biological_processcell-cell signaling
D0007623biological_processcircadian rhythm
D0008284biological_processpositive regulation of cell population proliferation
D0008286biological_processinsulin receptor signaling pathway
D0009435biological_processNAD biosynthetic process
D0016607cellular_componentnuclear speck
D0016757molecular_functionglycosyltransferase activity
D0019363biological_processpyridine nucleotide biosynthetic process
D0030054cellular_componentcell junction
D0032922biological_processcircadian regulation of gene expression
D0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
D0042802molecular_functionidentical protein binding
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0047280molecular_functionnicotinamide phosphoribosyltransferase activity
D0048511biological_processrhythmic process
D0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
D0060612biological_processadipose tissue development
D0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue J7F A 501
ChainResidue
AGLY185
AHOH613
ATYR188
AHIS191
AVAL242
AALA244
ASER275
AILE309
AILE351
AALA379

site_idAC2
Number of Residues2
Detailsbinding site for residue PO4 A 502
ChainResidue
AARG392
ALYS400

site_idAC3
Number of Residues5
Detailsbinding site for residue PO4 A 503
ChainResidue
AGLY197
AGLY383
AGLY384
AHOH692
BARG392

site_idAC4
Number of Residues9
Detailsbinding site for residue J7F B 501
ChainResidue
BTYR188
BHIS191
BPHE193
BVAL242
BALA244
BPRO273
BSER275
BILE351
BALA379

site_idAC5
Number of Residues5
Detailsbinding site for residue PO4 B 502
ChainResidue
BARG40
BARG392
BSER398
BLYS400
BHOH644

site_idAC6
Number of Residues13
Detailsbinding site for residue J7F C 501
ChainResidue
CGLY185
CTYR188
CHIS191
CPHE193
CVAL242
CALA244
CSER275
CILE351
CALA379
CHOH612
CHOH619
CHOH669
CHOH757

site_idAC7
Number of Residues4
Detailsbinding site for residue PO4 C 502
ChainResidue
CARG40
CARG392
CSER398
CLYS400

site_idAC8
Number of Residues4
Detailsbinding site for residue PO4 C 503
ChainResidue
CGLY383
CGLY384
CHOH611
DARG392

site_idAC9
Number of Residues13
Detailsbinding site for residue J7F D 501
ChainResidue
DGLY185
DTYR188
DHIS191
DPHE193
DVAL242
DALA244
DSER275
DILE351
DALA379
DHOH602
DHOH683
DHOH703
DHOH736

site_idAD1
Number of Residues6
Detailsbinding site for residue PO4 D 502
ChainResidue
DARG40
DARG392
DSER398
DLYS400
DHOH694
DHOH735

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsBINDING:
ChainResidueDetails
AARG196
BHIS247
BARG311
BGLY353
BGLY384
BARG392
CARG196
CASP219
CHIS247
CARG311
CGLY353
AASP219
CGLY384
CARG392
DARG196
DASP219
DHIS247
DARG311
DGLY353
DGLY384
DARG392
AHIS247
AARG311
AGLY353
AGLY384
AARG392
BARG196
BASP219

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895
ChainResidueDetails
AMET1
BMET1
CMET1
DMET1

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR188
BTYR188
CTYR188
DTYR188

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER472
BSER472
CSER472
DSER472

222036

PDB entries from 2024-07-03

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