7ENQ
Crystal structure of human NAMPT in complex with compound NAT
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Nicotinamide phosphoribosyltransferase | polymer | 497 | 56423.8 | 4 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) | Homo sapiens (Human) | NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin |
| 2 | E, H, J, M (A, B, C, D) | 2-(2-~{tert}-butylphenoxy)-~{N}-(4-hydroxyphenyl)ethanamide | non-polymer | 299.4 | 4 | Chemie (J7F) | |||
| 3 | F, G, I, K, L... (A, B, C, D) | PHOSPHATE ION | non-polymer | 95.0 | 6 | Chemie (PO4) | |||
| 4 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 596 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 491 (UniProt: P43490)
| PDB | External Database | Details |
|---|---|---|
| His 492 | - | expression tag |
| His 493 | - | expression tag |
| His 494 | - | expression tag |
| His 495 | - | expression tag |
| His 496 | - | expression tag |
| His 497 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 225695.2 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1767.3 | |
| All* | Total formula weight | 227462.5 |
