7ENQ

Crystal structure of human NAMPT in complex with compound NAT

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Nicotinamide phosphoribosyltransferase	polymer	497	56423.8	4	UniProt (P43490) Pfam (PF18127) Pfam (PF04095) In PDB	Homo sapiens (Human)	NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	A, B, C, D	2-(2-~{tert}-butylphenoxy)-~{N}-(4-hydroxyphenyl)ethanamide	non-polymer		299.4	4	Chemie (J7F)
3	A, B, C, D	PHOSPHATE ION	non-polymer		95.0	6	Chemie (PO4)
4		water	water		18.0	596	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
His 492	-	expression tag
His 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	225695.2
Non-Polymers*	Number of molecules	10
	Total formula weight	1767.3
All*	Total formula weight	227462.5

*Water molecules are not included.