5VSD
Structure of human GLP SET-domain (EHMT1) in complex with inhibitor 13
Summary for 5VSD
Entry DOI | 10.2210/pdb5vsd/pdb |
Related | 5VSC 5VSE 5VSF |
Descriptor | Histone-lysine N-methyltransferase EHMT1, S-ADENOSYLMETHIONINE, ZINC ION, ... (7 entities in total) |
Functional Keywords | protein-small molecule inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 62804.17 |
Authors | Babault, N.,Xiong, Y.,Liu, J.,Jin, J. (deposition date: 2017-05-11, release date: 2017-07-12, Last modification date: 2023-10-04) |
Primary citation | Xiong, Y.,Li, F.,Babault, N.,Wu, H.,Dong, A.,Zeng, H.,Chen, X.,Arrowsmith, C.H.,Brown, P.J.,Liu, J.,Vedadi, M.,Jin, J. Structure-activity relationship studies of G9a-like protein (GLP) inhibitors. Bioorg. Med. Chem., 25:4414-4423, 2017 Cited by PubMed: 28662962DOI: 10.1016/j.bmc.2017.06.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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