3PUQ
| CEKDM7A from C.Elegans, complex with alpha-KG | 分子名称: | 2-OXOGLUTARIC ACID, FE (II) ION, GLYCEROL, ... | 著者 | Yang, Y, Wang, P, Xu, W, Xu, Y. | 登録日 | 2010-12-06 | 公開日 | 2011-01-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases Cancer Cell, 19, 2011
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2I47
| Crystal structure of catalytic domain of TACE with inhibitor | 分子名称: | 4-({[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}METHYL)-1-[(3,5-DIMETHYLISOXAZOL-4-YL)SULFONYL]-N-HYDROXYPIPERIDINE-4-CARBOXAMIDE, ADAM 17, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... | 著者 | Xu, W, Condon, J.S, Lovering, F.E. | 登録日 | 2006-08-21 | 公開日 | 2006-12-05 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Identification of potent and selective TACE inhibitors via the S1 pocket. Bioorg.Med.Chem.Lett., 17, 2007
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3II5
| The Complex of wild-type B-RAF with Pyrazolo pyrimidine inhibitor | 分子名称: | B-Raf proto-oncogene serine/threonine-protein kinase, N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide, PHOSPHATE ION | 著者 | Xu, W, Breger, D, Torres, N, Dutia, M, Powell, D, Ciszewski, G. | 登録日 | 2009-07-31 | 公開日 | 2009-11-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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3G42
| Crystal Structure of TACE with Tryptophan Sulfonamide Derivative Inhibitor | 分子名称: | ADAM 17, N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan, ZINC ION | 著者 | Xu, W, Park, K, Gopalsamy, A, Aplasca, A, Zhang, Y.H, Levin, J.I. | 登録日 | 2009-02-03 | 公開日 | 2009-05-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors. Bioorg.Med.Chem., 17, 2009
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3H0E
| 3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as Potent Non-Peptidic Inhibitors of Caspase-3 | 分子名称: | (10S)-3,3-dimethyl-8-{[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl}-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol, Caspase-3 | 著者 | Xu, W. | 登録日 | 2009-04-09 | 公開日 | 2009-11-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | 3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3 Bioorg.Med.Chem., 17, 2009
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2HB1
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2H4G
| Crystal structure of PTP1B with monocyclic thiophene inhibitor | 分子名称: | 4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Xu, W, Wan, Z.-K. | 登録日 | 2006-05-24 | 公開日 | 2006-08-29 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48. Bioorg.Med.Chem.Lett., 16, 2006
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2H4K
| Crystal structure of PTP1B with a monocyclic thiophene inhibitor | 分子名称: | 4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Xu, W, Wan, Z.-K. | 登録日 | 2006-05-24 | 公開日 | 2006-08-29 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48. Bioorg.Med.Chem.Lett., 16, 2006
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2NTA
| Crystal Structure of PTP1B-inhibitor Complex | 分子名称: | 5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Xu, W, Follows, B. | 登録日 | 2006-11-07 | 公開日 | 2007-04-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Probing acid replacements of thiophene PTP1B inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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2NT7
| Crystal structure of PTP1B-inhibitor complex | 分子名称: | Tyrosine-protein phosphatase non-receptor type 1, {[5-(3-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}PHENYL)-4-BROMO-2-(2H-TETRAZOL-5-YL)-3-THIENYL]OXY}ACETIC ACID | 著者 | Xu, W, Follows, B. | 登録日 | 2006-11-07 | 公開日 | 2007-04-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Probing acid replacements of thiophene PTP1B inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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4M0Q
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7V4L
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7V4J
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7V4H
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7V4I
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7V4K
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7WHS
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7WHR
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7WHT
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4ZAH
| Crystal structure of sugar aminotransferase WecE with External Aldimine VII from Escherichia coli K-12 | 分子名称: | [[(2R,3S,5R)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3R,4S,5R,6R)-6-methyl-5-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3,4-bis(oxidanyl)oxan-2-yl] hydrogen phosphate, dTDP-4-amino-4,6-dideoxygalactose transaminase | 著者 | Wang, F, Singh, S, Cao, H, Xu, W, Miller, M.D, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2015-04-13 | 公開日 | 2015-04-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Structural Basis for the Stereochemical Control of Amine Installation in Nucleotide Sugar Aminotransferases. Acs Chem.Biol., 10, 2015
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4OO2
| Streptomyces globisporus C-1027 FAD dependent (S)-3-chloro-β-tyrosine-S-SgcC2 C-5 hydroxylase SgcC apo form | 分子名称: | CALCIUM ION, Chlorophenol-4-monooxygenase, GLYCEROL | 著者 | Cao, H, Xu, W, Bingman, C.A, Lohman, J.R, Yennamalli, R, Shen, B, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2014-01-29 | 公開日 | 2014-02-12 | 最終更新日 | 2023-03-22 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus. Biochemistry, 55, 2016
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6DA9
| Crystal structure of the TtnD decarboxylase from the tautomycetin biosynthesis pathway of Streptomyces griseochromogenes with FMN bound at 2.05 A resolution | 分子名称: | FLAVIN MONONUCLEOTIDE, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Han, L, Rudolf, J.D, Chang, C.-Y, Miller, M.D, Soman, J, Xu, W, Phillips Jr, G.N, Shen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2018-05-01 | 公開日 | 2018-10-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway. ACS Chem. Biol., 13, 2018
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3UTM
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3KO1
| Cystal structure of thermosome from Acidianus tengchongensis strain S5 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperonin | 著者 | Huo, Y, Zhang, K, Hu, Z, Wang, L, Zhai, Y, Zhou, Q, Lander, G, He, Y, Zhu, J, Xu, W, Dong, Z, Sun, F. | 登録日 | 2009-11-12 | 公開日 | 2010-11-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Crystal structure of group II chaperonin in the open state. Structure, 18, 2010
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7N7V
| Crystal structure of TtnM, a Fe(II)-alpha-ketoglutarate-dependent hydroxylase from the tautomycetin biosynthesis pathway in Streptomyces griseochromogenes at 2 A. | 分子名称: | CHLORIDE ION, FE (II) ION, Predicted hydroxylase | 著者 | Han, L, Xu, W, Ma, M, Miller, M.D, Shen, B, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2021-06-11 | 公開日 | 2022-07-06 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structure of TtnM, a Fe(II)-alpha-ketoglutarate-dependent hydroxylase from the tautomycetin biosynthesis pathway in Streptomyces griseochromogenes. To Be Published
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