2NT7

Crystal structure of PTP1B-inhibitor complex

Summary for 2NT7

Entry DOI	10.2210/pdb2nt7/pdb
Related	2H4G 2H4K 2HCE 2HCW 2HCX 2HFA 2NTA
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, {[5-(3-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}PHENYL)-4-BROMO-2-(2H-TETRAZOL-5-YL)-3-THIENYL]OXY}ACETIC ACID (3 entities in total)
Functional Keywords	ptp1b, protein-inhibitor complex, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	35453.23
Authors	Xu, W.,Follows, B. (deposition date: 2006-11-07, release date: 2007-04-17, Last modification date: 2023-12-27)
Primary citation	Wan, Z.K.,Follows, B.,Kirincich, S.,Wilson, D.,Binnun, E.,Xu, W.,Joseph-McCarthy, D.,Wu, J.,Smith, M.,Zhang, Y.L.,Tam, M.,Erbe, D.,Tam, S.,Saiah, E.,Lee, J. Probing acid replacements of thiophene PTP1B inhibitors. Bioorg.Med.Chem.Lett., 17:2913-2920, 2007 Cited by PubMed: 17336064 DOI: 10.1016/j.bmcl.2007.02.043 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation