2NT7
Crystal structure of PTP1B-inhibitor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 299 | 34819.7 | 1 | UniProt (P18031) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase 1B, PTP-1B |
| 2 | A | {[5-(3-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}PHENYL)-4-BROMO-2-(2H-TETRAZOL-5-YL)-3-THIENYL]OXY}ACETIC ACID | non-polymer | 633.5 | 1 | Chemie (902) | |||
| 3 | water | water | 18.0 | 186 | Chemie (HOH) |
Sequence modifications
A: 1 - 299 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Asp 252 | Glu 252 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34819.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 633.5 | |
| All* | Total formula weight | 35453.2 |
