4OO2

Streptomyces globisporus C-1027 FAD dependent (S)-3-chloro-β-tyrosine-S-SgcC2 C-5 hydroxylase SgcC apo form

Summary for 4OO2

• Entry DOI: 10.2210/pdb4oo2/pdb
• Related: 4HX6 4R82
• Descriptor: Chlorophenol-4-monooxygenase, CALCIUM ION, GLYCEROL, ... (4 entities in total)
• Functional Keywords: structural genomics, enzyme discovery for natural product biosynthesis, natpro, putative hpab-family monooxygenase, fad binding, oxidoreductase, psi-biology
• Biological source: Streptomyces globisporus
• Total number of polymer chains: 4
• Total formula weight: 235716.58

Authors

Cao, H.,Xu, W.,Bingman, C.A.,Lohman, J.R.,Yennamalli, R.,Shen, B.,Phillips Jr., G.N.,Enzyme Discovery for Natural Product Biosynthesis (NatPro) (deposition date: 2014-01-29, release date: 2014-02-12, Last modification date: 2023-03-22)

• Primary citation: Chang, C.Y.,Lohman, J.R.,Cao, H.,Tan, K.,Rudolf, J.D.,Ma, M.,Xu, W.,Bingman, C.A.,Yennamalli, R.M.,Bigelow, L.,Babnigg, G.,Yan, X.,Joachimiak, A.,Phillips, G.N.,Shen, B.; Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.; Biochemistry, 55:5142-5154, 2016; PubMed: 27560143; DOI: 10.1021/acs.biochem.6b00713

Experimental method

X-RAY DIFFRACTION (2.63 Å)