7WHT

Cryo-EM Structure of Leishmanial GDP-mannose pyrophosphorylase in complex with GDP-Mannose

Summary for 7WHT

Entry DOI	10.2210/pdb7wht/pdb
EMDB information	32511
Descriptor	Nucleotidyl transferase family protein, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, MAGNESIUM ION (3 entities in total)
Functional Keywords	protozoan enzyme, leishmania donovani, sugar binding protein
Biological source	Leishmania donovani
Total number of polymer chains	6
Total formula weight	254458.32
Authors	Xu, W.,Li, H.,Huang, C. (deposition date: 2021-12-31, release date: 2022-10-12, Last modification date: 2025-07-02)
Primary citation	Li, H.,Ji, T.,Sun, Q.,Chen, Y.,Xu, W.,Huang, C. Structural insights into selective inhibition of leishmanial GDP-mannose pyrophosphorylase. Cell Discov, 8:83-83, 2022 Cited by PubMed: 36038534 DOI: 10.1038/s41421-022-00424-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation