4ZAH

Crystal structure of sugar aminotransferase WecE with External Aldimine VII from Escherichia coli K-12

Replaces:  4WFP

Summary for 4ZAH

• Entry DOI: 10.2210/pdb4zah/pdb
• Related: 4PIW
• Descriptor: dTDP-4-amino-4,6-dideoxygalactose transaminase, [[(2R,3S,5R)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3R,4S,5R,6R)-6-methyl-5-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3,4-bis(oxidanyl)oxan-2-yl] hydrogen phosphate (3 entities in total)
• Functional Keywords: sugar aminotransferase, structural genomics, psi-biology, protein structure initiative, enzyme discovery for natural product biosynthesis, natpro, transferase
• Biological source: Escherichia coli (strain K12)
• Total number of polymer chains: 8
• Total formula weight: 359149.90

Authors

Wang, F.,Singh, S.,Cao, H.,Xu, W.,Miller, M.D.,Thorson, J.S.,Phillips Jr., G.N.,Enzyme Discovery for Natural Product Biosynthesis (NatPro) (deposition date: 2015-04-13, release date: 2015-04-29, Last modification date: 2023-09-27)

• Primary citation: Wang, F.,Singh, S.,Xu, W.,Helmich, K.E.,Miller, M.D.,Cao, H.,Bingman, C.A.,Thorson, J.S.,Phillips, G.N.; Structural Basis for the Stereochemical Control of Amine Installation in Nucleotide Sugar Aminotransferases.; Acs Chem.Biol., 10:2048-2056, 2015; PubMed: 26023720; DOI: 10.1021/acschembio.5b00244

Experimental method

X-RAY DIFFRACTION (2.24 Å)