3E6O
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![BU of 3e6o by Molmil](/molmil-images/mine/3e6o) | Structure of murine INOS oxygenase domain with inhibitor AR-C124355 | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE, Nitric oxide synthase, ... | 著者 | Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stueh, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. | 登録日 | 2008-08-15 | 公開日 | 2008-10-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4, 2008
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3E7G
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![BU of 3e7g by Molmil](/molmil-images/mine/3e7g) | Structure of human INOSOX with inhibitor AR-C95791 | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE, Nitric oxide synthase, ... | 著者 | Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stueh, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. | 登録日 | 2008-08-18 | 公開日 | 2008-10-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4, 2008
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4YEX
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![BU of 4yex by Molmil](/molmil-images/mine/4yex) | HUaa-19bp | 分子名称: | DNA-binding protein HU-alpha, synthetic DNA strand | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | 登録日 | 2015-02-24 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
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4YFT
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![BU of 4yft by Molmil](/molmil-images/mine/4yft) | HUab-20bp | 分子名称: | DNA-binding protein HU-alpha, DNA-binding protein HU-beta, synthetic DNA strand | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | 登録日 | 2015-02-25 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.914 Å) | 主引用文献 | HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
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4YEW
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![BU of 4yew by Molmil](/molmil-images/mine/4yew) | HUab-19bp | 分子名称: | DNA-binding protein HU-alpha, DNA-binding protein HU-beta, synthetic DNA strand | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | 登録日 | 2015-02-24 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.683 Å) | 主引用文献 | HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
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4YEY
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![BU of 4yey by Molmil](/molmil-images/mine/4yey) | HUaa-20bp | 分子名称: | DNA-binding protein HU-alpha, synthetic DNA strand | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | 登録日 | 2015-02-24 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.354 Å) | 主引用文献 | HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
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4YFH
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![BU of 4yfh by Molmil](/molmil-images/mine/4yfh) | HU38-20bp | 分子名称: | DNA-binding protein HU-alpha, synthetic DNA strand | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | 登録日 | 2015-02-25 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
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4YF0
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![BU of 4yf0 by Molmil](/molmil-images/mine/4yf0) | HU38-19bp | 分子名称: | DNA-binding protein HU-alpha, synthetic DNA strand | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | 登録日 | 2015-02-24 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
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6MUJ
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![BU of 6muj by Molmil](/molmil-images/mine/6muj) | Formylglycine generating enzyme bound to copper | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CALCIUM ION, COPPER (II) ION, ... | 著者 | Lafrance-Vanasse, J, Appel, M.J, Tsai, C.-L, Bertozzi, C, Tainer, J.A. | 登録日 | 2018-10-23 | 公開日 | 2019-02-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.249 Å) | 主引用文献 | Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2activation. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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1UGH
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![BU of 1ugh by Molmil](/molmil-images/mine/1ugh) | CRYSTAL STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE IN COMPLEX WITH A PROTEIN INHIBITOR: PROTEIN MIMICRY OF DNA | 分子名称: | PROTEIN (URACIL-DNA GLYCOSYLASE INHIBITOR), PROTEIN (URACIL-DNA GLYCOSYLASE) | 著者 | Mol, C.D, Arvai, A.S, Sanderson, R.J, Slupphaug, G, Kavli, B, Krokan, H.E, Mosbaugh, D.W, Tainer, J.A. | 登録日 | 1999-02-05 | 公開日 | 1999-02-16 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA. Cell(Cambridge,Mass.), 82, 1995
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4SKN
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![BU of 4skn by Molmil](/molmil-images/mine/4skn) | A NUCLEOTIDE-FLIPPING MECHANISM FROM THE STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO DNA | 分子名称: | DNA (5'-D(*AP*AP*AP*GP*CP*CP*GP*CP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*GP*(D1P)P*GP*GP*CP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE), ... | 著者 | Slupphaug, G, Mol, C.D, Kavli, B, Arvai, A.S, Krokan, H.E, Tainer, J.A. | 登録日 | 1999-02-20 | 公開日 | 1999-02-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature, 384, 1996
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5KSE
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![BU of 5kse by Molmil](/molmil-images/mine/5kse) | Flap endonuclease 1 (FEN1) R100A with 5'-flap substrate DNA and Sm3+ | 分子名称: | DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*AP*AP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ... | 著者 | Tsutakawa, S.E, Arvai, A.S, Tainer, J.A. | 登録日 | 2016-07-08 | 公開日 | 2017-06-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.105 Å) | 主引用文献 | Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability. Nat Commun, 8, 2017
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4TWS
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![BU of 4tws by Molmil](/molmil-images/mine/4tws) | Gadolinium Derivative of Tetragonal Hen Egg-White Lysozyme at 1.45 A Resolution | 分子名称: | 10-((2R)-2-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLODODECANE 1,4,7-TRIACETIC ACID, CHLORIDE ION, GADOLINIUM ATOM, ... | 著者 | Holton, J.M, Classen, S, Frankel, K.A, Tainer, J.A. | 登録日 | 2014-07-01 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | The R-factor gap in macromolecular crystallography: an untapped potential for insights on accurate structures. Febs J., 281, 2014
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2W35
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![BU of 2w35 by Molmil](/molmil-images/mine/2w35) | Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair | 分子名称: | 5'-D(*AP*GP*CP*CP*GP*TP)-3', 5'-D(*AP*TP*GP*CP*GP*AP*CP*IP*GP)-3', Endonuclease V, ... | 著者 | Dalhus, B, Arvai, A.S, Rosnes, I, Olsen, O.E, Backe, P.H, Alseth, I, Gao, H, Cao, W, Tainer, J.A, Bjoras, M. | 登録日 | 2008-11-06 | 公開日 | 2009-01-20 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structures of Endonuclease V with DNA Reveal Initiation of Deaminated Adenine Repair. Nat.Struct.Mol.Biol., 16, 2009
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5KVH
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![BU of 5kvh by Molmil](/molmil-images/mine/5kvh) | Crystal structure of human apoptosis-inducing factor with W196A mutation | 分子名称: | Apoptosis-inducing factor 1, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Brosey, C.A, Nix, J, Ellenberger, T, Tainer, J.A. | 登録日 | 2016-07-14 | 公開日 | 2016-11-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.273 Å) | 主引用文献 | Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor. Structure, 24, 2016
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5KVI
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![BU of 5kvi by Molmil](/molmil-images/mine/5kvi) | Crystal structure of monomeric human apoptosis-inducing factor with E413A/R422A/R430A mutations | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Apoptosis-inducing factor 1, mitochondrial, ... | 著者 | Brosey, C.A, Nix, J, Ellenberger, T, Tainer, J.A. | 登録日 | 2016-07-14 | 公開日 | 2016-11-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | 主引用文献 | Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor. Structure, 24, 2016
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6VBH
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![BU of 6vbh by Molmil](/molmil-images/mine/6vbh) | Human XPG endonuclease catalytic domain | 分子名称: | DNA repair protein complementing XP-G cells,Flap endonuclease 1, SULFATE ION | 著者 | Tsutakawa, S.E, Arvai, A.S, Tainer, J.A. | 登録日 | 2019-12-18 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | 主引用文献 | Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations. Proc.Natl.Acad.Sci.USA, 117, 2020
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6VBA
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![BU of 6vba by Molmil](/molmil-images/mine/6vba) | Structure of human Uracil DNA Glycosylase (UDG) bound to Aurintricarboxylic acid (ATA) | 分子名称: | 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene]bis(6-hydroxybenzoic acid), Uracil-DNA glycosylase | 著者 | Moiani, D, Arvai, A.S, Tainer, J.A. | 登録日 | 2019-12-18 | 公開日 | 2021-03-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation. Prog.Biophys.Mol.Biol., 163, 2021
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3L41
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![BU of 3l41 by Molmil](/molmil-images/mine/3l41) | Crystal Structure of S. pombe Brc1 BRCT5-BRCT6 domains in complex with phosphorylated H2A | 分子名称: | BRCT-containing protein 1, phosphorylated H2A tail | 著者 | Williams, R.S, Williams, J.S, Guenther, G, Tainer, J.A. | 登録日 | 2009-12-18 | 公開日 | 2010-02-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | gammaH2A binds Brc1 to maintain genome integrity during S-phase. Embo J., 29, 2010
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3L2P
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![BU of 3l2p by Molmil](/molmil-images/mine/3l2p) | Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States | 分子名称: | 5'-D(*GP*CP*CP*AP*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*CP*CP*G)-3', 5'-D(*GP*TP*CP*GP*GP*AP*CP*TP*G)-3', 5'-D(P*CP*GP*GP*GP*AP*TP*GP*CP*GP*TP*C)-3', ... | 著者 | Cotner-Gohara, E.A, Kim, I.K, Hammel, M, Tainer, J.A, Tomkinson, A, Ellenberger, T. | 登録日 | 2009-12-15 | 公開日 | 2010-07-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching between Two DNA-Bound States. Biochemistry, 49, 2010
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3L40
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4L05
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![BU of 4l05 by Molmil](/molmil-images/mine/4l05) | Cu/Zn superoxide dismutase from Brucella abortus | 分子名称: | COPPER (I) ION, COPPER (II) ION, GLYCEROL, ... | 著者 | Shin, D.S, Didonato, M, Pratt, A.J, Bruns, C.K, Cabelli, D.E, Kroll, J.S, Belzer, C.A, Tabatabai, L.B, Tainer, J.A, Getzoff, E.D. | 登録日 | 2013-05-30 | 公開日 | 2013-10-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.098 Å) | 主引用文献 | Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus. J.Bacteriol., 197, 2015
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6WH1
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![BU of 6wh1 by Molmil](/molmil-images/mine/6wh1) | Structure of the complex of human DNA ligase III-alpha and XRCC1 BRCT domains | 分子名称: | DNA ligase 3 alpha, X-ray repair cross complementing protein 1 variant | 著者 | Pourfarjam, Y, Ellenberger, T, Tainer, J.A, Tomkinson, A.E, Kim, I.K. | 登録日 | 2020-04-07 | 公開日 | 2020-12-02 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III alpha within a flexible DNA repair complex. Nucleic Acids Res., 49, 2021
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6X1Z
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![BU of 6x1z by Molmil](/molmil-images/mine/6x1z) | Mre11 dimer in complex with small molecule modulator PFMJ | 分子名称: | (5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, ... | 著者 | Arvai, A.S, Moiani, D, Tainer, J.A. | 登録日 | 2020-05-19 | 公開日 | 2020-06-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response. Prog.Biophys.Mol.Biol., 163, 2021
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5E7O
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![BU of 5e7o by Molmil](/molmil-images/mine/5e7o) | Crystal structure of the perchlorate reductase PcrAB mutant W461E of PcrA from Azospira suillum PS | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, DMSO reductase family type II enzyme, ... | 著者 | Tsai, C.-L, Tainer, J.A. | 登録日 | 2015-10-12 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Perchlorate Reductase Is Distinguished by Active Site Aromatic Gate Residues. J.Biol.Chem., 291, 2016
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