6VBH

Human XPG endonuclease catalytic domain

Summary for 6VBH

• Entry DOI: 10.2210/pdb6vbh/pdb
• Descriptor: DNA repair protein complementing XP-G cells,Flap endonuclease 1, SULFATE ION (3 entities in total)
• Functional Keywords: metalloprotein, replication, dna damage, dna repair, nucloetide excision repair, xpg, xeroderma pigmentosum, 5' nuclease, hydrolase-dna complex, dna binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 41561.82

Authors

Tsutakawa, S.E.,Arvai, A.S.,Tainer, J.A. (deposition date: 2019-12-18, release date: 2020-06-17, Last modification date: 2023-10-11)

• Primary citation: Tsutakawa, S.E.,Sarker, A.H.,Ng, C.,Arvai, A.S.,Shin, D.S.,Shih, B.,Jiang, S.,Thwin, A.C.,Tsai, M.S.,Willcox, A.,Her, M.Z.,Trego, K.S.,Raetz, A.G.,Rosenberg, D.,Bacolla, A.,Hammel, M.,Griffith, J.D.,Cooper, P.K.,Tainer, J.A.; Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.; Proc.Natl.Acad.Sci.USA, 117:14127-14138, 2020; PubMed: 32522879; DOI: 10.1073/pnas.1921311117

Experimental method

X-RAY DIFFRACTION (1.995 Å)