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6VBH

Human XPG endonuclease catalytic domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003697molecular_functionsingle-stranded DNA binding
A0003824molecular_functioncatalytic activity
A0004518molecular_functionnuclease activity
A0004519molecular_functionendonuclease activity
A0005634cellular_componentnucleus
A0006289biological_processnucleotide-excision repair
A0016788molecular_functionhydrolase activity, acting on ester bonds
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue SO4 A 1001
ChainResidue
AASP847
AASN849
ALYS850
AHIS884
AGLY885

site_idAC2
Number of Residues6
Detailsbinding site for residue SO4 A 1002
ChainResidue
ACYS871
AHOH1136
AGLN4
AGLY5
ALYS8
AGLY870

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 A 1003
ChainResidue
ALYS952
AARG970
AHOH1102

site_idAC4
Number of Residues7
Detailsbinding site for residue SO4 A 1004
ChainResidue
ALEU83
ALYS85
ATHR863
AGLU864
AHOH1128
AHOH1134
AHOH1152

site_idAC5
Number of Residues3
Detailsbinding site for residue SO4 A 1005
ChainResidue
AARG819
ATYR837
AHOH1122

site_idAC6
Number of Residues4
Detailsbinding site for residue SO4 A 1006
ChainResidue
ATRP34
AGLN37
AHIS54
ATHR57

site_idAC7
Number of Residues3
Detailsbinding site for residue SO4 A 1007
ChainResidue
ATRP895
AASP911
AARG919

site_idAC8
Number of Residues5
Detailsbinding site for residue SO4 A 1008
ChainResidue
APRO867
ATHR868
AVAL869
AHOH1110
AHOH1132

site_idAC9
Number of Residues5
Detailsbinding site for residue SO4 A 1009
ChainResidue
APRO782
ATYR783
ATHR912
AHOH1143
AHOH1167

site_idAD1
Number of Residues2
Detailsbinding site for residue SO4 A 1010
ChainResidue
AARG970
AHOH1150

site_idAD2
Number of Residues3
Detailsbinding site for residue SO4 A 1011
ChainResidue
ATHR57
AHIS60
AHOH1141

site_idAD3
Number of Residues4
Detailsbinding site for residue SO4 A 1012
ChainResidue
ALEU66
ATRP950
AGLY951
AHOH1176

site_idAD4
Number of Residues3
Detailsbinding site for residue SO4 A 1013
ChainResidue
AARG94
AARG98
AARG126

site_idAD5
Number of Residues4
Detailsbinding site for residue SO4 A 1014
ChainResidue
AARG98
AARG126
AGLY845
AHOH1130

site_idAD6
Number of Residues1
Detailsbinding site for residue SO4 A 1015
ChainResidue
AARG777

Functional Information from PROSITE/UniProt
site_idPS00841
Number of Residues15
DetailsXPG_1 XPG protein signature 1. IRPiFVFDGdaPlLK
ChainResidueDetails
AILE70-LYS84

site_idPS00842
Number of Residues15
DetailsXPG_2 XPG protein signature 2. GIPYIqAPmEAEAQC
ChainResidueDetails
AGLY780-CYS794

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00614
ChainResidueDetails
AASP30
ALEU83

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P39748
ChainResidueDetails
AASP77
AGLU789
AGLU791
AASP810
AASP812
AASP861

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS8

226707

PDB entries from 2024-10-30

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