5KSE

Flap endonuclease 1 (FEN1) R100A with 5'-flap substrate DNA and Sm3+

Summary for 5KSE

• Entry DOI: 10.2210/pdb5kse/pdb
• Descriptor: Flap endonuclease 1, DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*AP*AP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ... (7 entities in total)
• Functional Keywords: metalloprotein, replication, dna damage, dna repair, base excision repair, protein-dna, nuclease, fen, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 51728.15

Authors

Tsutakawa, S.E.,Arvai, A.S.,Tainer, J.A. (deposition date: 2016-07-08, release date: 2017-06-28, Last modification date: 2024-03-06)

• Primary citation: Tsutakawa, S.E.,Thompson, M.J.,Arvai, A.S.,Neil, A.J.,Shaw, S.J.,Algasaier, S.I.,Kim, J.C.,Finger, L.D.,Jardine, E.,Gotham, V.J.B.,Sarker, A.H.,Her, M.Z.,Rashid, F.,Hamdan, S.M.,Mirkin, S.M.,Grasby, J.A.,Tainer, J.A.; Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.; Nat Commun, 8:15855-15855, 2017; PubMed: 28653660; DOI: 10.1038/ncomms15855

Experimental method

X-RAY DIFFRACTION (2.105 Å)