6X1Z

Mre11 dimer in complex with small molecule modulator PFMJ

Summary for 6X1Z

Entry DOI	10.2210/pdb6x1z/pdb
Descriptor	Nuclease SbcCD subunit D, (5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	dna repair mre11 thermophilic nuclease, dna double-strand break repair, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Thermotoga maritima
Total number of polymer chains	2
Total formula weight	78152.22
Authors	Arvai, A.S.,Moiani, D.,Tainer, J.A. (deposition date: 2020-05-19, release date: 2020-06-10, Last modification date: 2023-10-18)
Primary citation	Wilson 3rd, D.M.,Deacon, A.M.,Duncton, M.A.J.,Pellicena, P.,Georgiadis, M.M.,Yeh, A.P.,Arvai, A.S.,Moiani, D.,Tainer, J.A.,Das, D. Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response. Prog.Biophys.Mol.Biol., 163:130-142, 2021 Cited by PubMed: 33115610 DOI: 10.1016/j.pbiomolbio.2020.10.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation